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Rational design and in vivo validation of capsid inhibitors for enterovirus D68.

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Title: Rational design and in vivo validation of capsid inhibitors for enterovirus D68.
Authors: Li K; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Rudy MJ; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Klose T; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Tan H; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Wu X; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA., Demssie HA; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Anderson JS; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Jadhav P; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA., Zhang QY; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA., Clarke P; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA., Kuhn RJ; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. kuhnr@purdue.edu.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA. kuhnr@purdue.edu., Tyler KL; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Department of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Neurology Service, Rocky Mountain VA Medical Center, Aurora, CO, USA. ken.tyler@cuanschutz.edu., Wang J; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. junwang@pharmacy.rutgers.edu.
Source: Nature communications [Nat Commun] 2026 Feb 10; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Rudy+MJ%22">Rudy MJ</searchLink>; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Klose+T%22">Klose T</searchLink>; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Tan+H%22">Tan H</searchLink>; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Demssie+HA%22">Demssie HA</searchLink>; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+JS%22">Anderson JS</searchLink>; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Jadhav+P%22">Jadhav P</searchLink>; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+QY%22">Zhang QY</searchLink>; Department of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+P%22">Clarke P</searchLink>; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Kuhn+RJ%22">Kuhn RJ</searchLink>; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. kuhnr@purdue.edu.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, USA. kuhnr@purdue.edu.<br /><searchLink fieldCode="AU" term="%22Tyler+KL%22">Tyler KL</searchLink>; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Department of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. ken.tyler@cuanschutz.edu.; Neurology Service, Rocky Mountain VA Medical Center, Aurora, CO, USA. ken.tyler@cuanschutz.edu.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. junwang@pharmacy.rutgers.edu.
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