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An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models.

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Title: An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models.
Authors: Ontoria JM; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy. j.ontoria@irbm.com., Torrente E; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Missineo A; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Alli C; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Graziani R; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Conti S; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Bisbocci M; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Quotadamo A; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Ferrigno F; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Corio A; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Ievoli G; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Bencheva L; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Sibylla Biotech S.p.A., Bresso, Italy., Amaudrut J; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Vasile S; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Beghetto E; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Paolini C; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Alaimo N; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Veneziano M; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Nibbio M; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Orsale MV; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Proto G; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Colaceci F; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Orsatti L; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Pucci V; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Johnson & Johnson, Beerse, Belgium., Di Fabio R; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Drug Discovery Unit, Vita Salute San Raffaele University, Milan, Italy., Tomei L; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy., Montalbetti C; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy., Bresciani A; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.; Tycho S.r.l., Bergamo, Italy., Toniatti C; CSO, IRBM S.p.A., Pomezia, Italy., Paonessa G; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy. g.paonessa@irbm.com.
Source: Nature communications [Nat Commun] 2026 Feb 10; Vol. 17 (1), pp. 1439. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models.
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  Data: <searchLink fieldCode="AU" term="%22Ontoria+JM%22">Ontoria JM</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy. j.ontoria@irbm.com.<br /><searchLink fieldCode="AU" term="%22Torrente+E%22">Torrente E</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Missineo+A%22">Missineo A</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Alli+C%22">Alli C</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Graziani+R%22">Graziani R</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+S%22">Conti S</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Bisbocci+M%22">Bisbocci M</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Quotadamo+A%22">Quotadamo A</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrigno+F%22">Ferrigno F</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Corio+A%22">Corio A</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Ievoli+G%22">Ievoli G</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Bencheva+L%22">Bencheva L</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Sibylla Biotech S.p.A., Bresso, Italy.<br /><searchLink fieldCode="AU" term="%22Amaudrut+J%22">Amaudrut J</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Vasile+S%22">Vasile S</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Beghetto+E%22">Beghetto E</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Paolini+C%22">Paolini C</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Alaimo+N%22">Alaimo N</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Veneziano+M%22">Veneziano M</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Nibbio+M%22">Nibbio M</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Orsale+MV%22">Orsale MV</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Proto+G%22">Proto G</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Colaceci+F%22">Colaceci F</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Orsatti+L%22">Orsatti L</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Pucci+V%22">Pucci V</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Johnson & Johnson, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Di+Fabio+R%22">Di Fabio R</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.; Drug Discovery Unit, Vita Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tomei+L%22">Tomei L</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Montalbetti+C%22">Montalbetti C</searchLink>; Department of Drug Discovery, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Bresciani+A%22">Bresciani A</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy.; Tycho S.r.l., Bergamo, Italy.<br /><searchLink fieldCode="AU" term="%22Toniatti+C%22">Toniatti C</searchLink>; CSO, IRBM S.p.A., Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Paonessa+G%22">Paonessa G</searchLink>; Department of Biology and Translational Research, IRBM S.p.A., Pomezia, Italy. g.paonessa@irbm.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 10; Vol. 17 (1), pp. 1439. <i>Date of Electronic Publication: </i>2026 Feb 10.
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