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Validation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane.

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Title: Validation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane.
Authors: Kubeczko M; Breast Cancer Center, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland., Cobo S; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Sanchez-Bayona R; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain., Pyciński B; Faculty of Biomedical Engineering, Silesian University of Technology, Zabrze, Poland., Soberino J; Breast Cancer Unit, IOB-QuirónSalud, Barcelona, Spain., Chmielik E; Tumor Pathology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland., Sanfeliu E; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Pathology Department, Hospital Clinic of Barcelona, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain., Rey M; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Pardo F; Reveal Genomics, Barcelona, Spain., Aguirre A; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Castillo O; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain., Lesniak A; Breast Cancer Center, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland., Oczko-Wojciechowska M; Department of Clinical and Molecular Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland., Carcelero E; Pharmacy Department, Hospital Clinic Barcelona, Barcelona, Spain., Adamo B; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain., Vidal M; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain., Bergamino M; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain., Maues J; GRASP, GRASP, Baltimore, MD, USA., Villacampa G; Statistics Unit, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Paré L; Reveal Genomics, Barcelona, Spain., Villagrasa P; Reveal Genomics, Barcelona, Spain., Ciruelos E; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain., Prat A; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Reveal Genomics, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain., Jarzab M; Breast Cancer Center, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland., Brasó-Maristany F; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. FBRASO@recerca.clinic.cat.; Reveal Genomics, Barcelona, Spain. FBRASO@recerca.clinic.cat.
Source: NPJ breast cancer [NPJ Breast Cancer] 2026 Feb 10; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
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  Data: Validation of the HER2DX genomic test in first-line advanced HER2-positive breast cancer treated with trastuzumab, pertuzumab, and taxane.
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  Data: <searchLink fieldCode="AU" term="%22Kubeczko+M%22">Kubeczko M</searchLink>; Breast Cancer Center, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.<br /><searchLink fieldCode="AU" term="%22Cobo+S%22">Cobo S</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sanchez-Bayona+R%22">Sanchez-Bayona R</searchLink>; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pyciński+B%22">Pyciński B</searchLink>; Faculty of Biomedical Engineering, Silesian University of Technology, Zabrze, Poland.<br /><searchLink fieldCode="AU" term="%22Soberino+J%22">Soberino J</searchLink>; Breast Cancer Unit, IOB-QuirónSalud, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Chmielik+E%22">Chmielik E</searchLink>; Tumor Pathology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.<br /><searchLink fieldCode="AU" term="%22Sanfeliu+E%22">Sanfeliu E</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Pathology Department, Hospital Clinic of Barcelona, Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rey+M%22">Rey M</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pardo+F%22">Pardo F</searchLink>; Reveal Genomics, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Aguirre+A%22">Aguirre A</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castillo+O%22">Castillo O</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lesniak+A%22">Lesniak A</searchLink>; Breast Cancer Center, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.<br /><searchLink fieldCode="AU" term="%22Oczko-Wojciechowska+M%22">Oczko-Wojciechowska M</searchLink>; Department of Clinical and Molecular Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.<br /><searchLink fieldCode="AU" term="%22Carcelero+E%22">Carcelero E</searchLink>; Pharmacy Department, Hospital Clinic Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Adamo+B%22">Adamo B</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vidal+M%22">Vidal M</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bergamino+M%22">Bergamino M</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Maues+J%22">Maues J</searchLink>; GRASP, GRASP, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Villacampa+G%22">Villacampa G</searchLink>; Statistics Unit, Vall d'Hebron Institute of Oncology, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Paré+L%22">Paré L</searchLink>; Reveal Genomics, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Villagrasa+P%22">Villagrasa P</searchLink>; Reveal Genomics, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ciruelos+E%22">Ciruelos E</searchLink>; Medical Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Prat+A%22">Prat A</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.; Department of Medicine, University of Barcelona, Barcelona, Spain.; Reveal Genomics, Barcelona, Spain.; Clínic Barcelona Comprehensive Cancer Center, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Jarzab+M%22">Jarzab M</searchLink>; Breast Cancer Center, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland.<br /><searchLink fieldCode="AU" term="%22Brasó-Maristany+F%22">Brasó-Maristany F</searchLink>; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain. FBRASO@recerca.clinic.cat.; Reveal Genomics, Barcelona, Spain. FBRASO@recerca.clinic.cat.
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  Data: <searchLink fieldCode="JN" term="%22101674891%22">NPJ breast cancer</searchLink> [NPJ Breast Cancer] 2026 Feb 10; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Feb 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Breast+Cancer+Research+Foundation%22">Breast Cancer Research Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101674891 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2374-4677 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223744677%22">23744677 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Breast Cancer <i>Subsets: </i>PubMed not MEDLINE
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