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Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness.

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Title: Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness.
Authors: Elami T; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.; Department of Anesthesiology, Intensive Care and Pain, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Zhu H; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel., Bruck-Haimson R; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel., Srivastava V; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel., Zaretsky A; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel., Cohen I; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel., Gross E; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel., Cohen E; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel. ehudc@ekmd.huji.ac.il.
Source: Scientific reports [Sci Rep] 2026 Feb 10; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness.
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  Data: <searchLink fieldCode="AU" term="%22Elami+T%22">Elami T</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.; Department of Anesthesiology, Intensive Care and Pain, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Bruck-Haimson+R%22">Bruck-Haimson R</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Srivastava+V%22">Srivastava V</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Zaretsky+A%22">Zaretsky A</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Cohen+I%22">Cohen I</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Gross+E%22">Gross E</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Cohen+E%22">Cohen E</searchLink>; Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel. ehudc@ekmd.huji.ac.il.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Feb 10; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Feb 10.
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        Value: 10.1038/s41598-026-38591-8
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              Text: 2026 Feb 10
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