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Integrative metabolomics and proteomics reveal early cardiovascular risk signatures in PCOS female offspring.

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Title: Integrative metabolomics and proteomics reveal early cardiovascular risk signatures in PCOS female offspring.
Authors: Wu X; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China., Deng X; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China., Liu S; Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China., Xie A; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China., Yang Y; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China., Wang H; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China., Zhu Y; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. zhuyim@zju.edu.cn.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. zhuyim@zju.edu.cn.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. zhuyim@zju.edu.cn., Tang M; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. tangmy@zju.edu.cn.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. tangmy@zju.edu.cn.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. tangmy@zju.edu.cn.
Source: Journal of ovarian research [J Ovarian Res] 2026 Feb 10; Vol. 19 (1), pp. 72. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative metabolomics and proteomics reveal early cardiovascular risk signatures in PCOS female offspring.
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  Data: <searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Xie+A%22">Xie A</searchLink>; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. zhuyim@zju.edu.cn.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. zhuyim@zju.edu.cn.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. zhuyim@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+M%22">Tang M</searchLink>; Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. tangmy@zju.edu.cn.; Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. tangmy@zju.edu.cn.; Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. tangmy@zju.edu.cn.
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        Value: 10.1186/s13048-026-02019-8
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              Text: 2026 Feb 10
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