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Single-Pill Low-Dose Triple Combination Therapy vs Standard-Dose Monotherapy in Patients With Mild-to-Moderate Hypertension.

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Title: Single-Pill Low-Dose Triple Combination Therapy vs Standard-Dose Monotherapy in Patients With Mild-to-Moderate Hypertension.
Authors: Sung KC; Division of Cardiology, Kangbuk Samsung Hospital, Seoul, Republic of Korea., Park K; Division of Cardiology, Dong-A University Hospital, Busan, Republic of Korea., Kim DH; Division of Cardiology, Asan Medical Center, Seoul, Republic of Korea., Lim SW; Cardiology Division, CHA Bundang Medical Center, Seongnam, Republic of Korea., Hong SJ; Department of Cardiology, Korea University Anam Hospital, Seoul, Republic of Korea., Lee JB; Department of Cardiology, Daegu Catholic University Medical Center, Daegu, Republic of Korea., Ryu DR; Division of Cardiology, Kangwon National University Hospital, Chuncheon, Republic of Korea., Kim SH; Division of Cardiology, Korea University Ansan Hospital, Ansan, Gyeonggi, Republic of Korea., Kim MC; Division of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea., Kim NY; Hanmi Pharmaceutical Co, Seoul, Republic of Korea., Parati G; Department of Cardiovascular, Neural, and Metabolic Sciences, Istituto Auxologico Italiano IRCCS, San Luca Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Rhee MY; Division of Cardiology, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi, Republic of Korea. Electronic address: mooyong.rhee@gmail.com.
Corporate Authors: HM-APOLLO 301 and 302 Trials Investigators
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 May 12; Vol. 87 (18), pp. 2392-2411. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Comparative Study
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Single-Pill Low-Dose Triple Combination Therapy vs Standard-Dose Monotherapy in Patients With Mild-to-Moderate Hypertension.
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  Data: <searchLink fieldCode="AU" term="%22Sung+KC%22">Sung KC</searchLink>; Division of Cardiology, Kangbuk Samsung Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+K%22">Park K</searchLink>; Division of Cardiology, Dong-A University Hospital, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+DH%22">Kim DH</searchLink>; Division of Cardiology, Asan Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+SW%22">Lim SW</searchLink>; Cardiology Division, CHA Bundang Medical Center, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+SJ%22">Hong SJ</searchLink>; Department of Cardiology, Korea University Anam Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JB%22">Lee JB</searchLink>; Department of Cardiology, Daegu Catholic University Medical Center, Daegu, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ryu+DR%22">Ryu DR</searchLink>; Division of Cardiology, Kangwon National University Hospital, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Division of Cardiology, Korea University Ansan Hospital, Ansan, Gyeonggi, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+MC%22">Kim MC</searchLink>; Division of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+NY%22">Kim NY</searchLink>; Hanmi Pharmaceutical Co, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Parati+G%22">Parati G</searchLink>; Department of Cardiovascular, Neural, and Metabolic Sciences, Istituto Auxologico Italiano IRCCS, San Luca Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rhee+MY%22">Rhee MY</searchLink>; Division of Cardiology, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi, Republic of Korea. Electronic address: mooyong.rhee@gmail.com.
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  Data: <searchLink fieldCode="CA" term="%22HM-APOLLO+301+and+302+Trials+Investigators%22">HM-APOLLO 301 and 302 Trials Investigators</searchLink>
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  Data: <searchLink fieldCode="JN" term="%228301365%22">Journal of the American College of Cardiology</searchLink> [J Am Coll Cardiol] 2026 May 12; Vol. 87 (18), pp. 2392-2411. <i>Date of Electronic Publication: </i>2026 Feb 11.
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        Value: 10.1016/j.jacc.2025.12.028
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        Text: English
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              Text: 2026 May 12
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