Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO.
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| Title: | Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO. |
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| Authors: | Li Z; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. zifan.li@biogen.com., Nguyen T; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA., Zhou X; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA., Xiao L; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA., Bou-Assaf GM; Pharmaceutical Operations & Technology, Biogen, 225 Binney Street, Cambridge, MA, 02142, USA. george.bou-assaf@biogen.com. |
| Source: | Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2026 Apr; Vol. 418 (8), pp. 2415-2425. Date of Electronic Publication: 2026 Feb 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1618-2650 |
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| DOI: | 10.1007/s00216-026-06370-z |
