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Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas.

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Title: Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas.
Authors: Batsios G; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA., Taglang C; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA., Udutha S; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA., Gillespie AM; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA., Phoenix T; Division of Pharmaceutical Sciences, University of Cincinnati, College of Pharmacy, Cincinnati, OH 45267, USA., Mueller S; Departments of Neurology, Neurological Surgery, and Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA., Venneti S; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Koschmann C; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA., Viswanath P; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Feb 11; Vol. 18 (836), pp. eadw0834. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas.
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              Text: 2026 Feb 11
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