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Machine Learning-Guided Engineering of Protein Phase Separation Properties in Immune Regulation.

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Title: Machine Learning-Guided Engineering of Protein Phase Separation Properties in Immune Regulation.
Authors: Zhang C; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Wang J; College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China., Wang Z; College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China., Zhu L; College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China., Cai S; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Zhan L; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Liang H; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Wu Y; Department of Critical Care Medicine, Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China., Li J; School of Artificial Intelligence, National Engineering Laboratory for Big Data System Computing Technology, Shenzhen University, Shenzhen, Guangdong, China., Cui J; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Apr; Vol. 13 (22), pp. e20890. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Zhu+L%22">Zhu L</searchLink>; College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Cai+S%22">Cai S</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhan+L%22">Zhan L</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Critical Care Medicine, Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; School of Artificial Intelligence, National Engineering Laboratory for Big Data System Computing Technology, Shenzhen University, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Cui+J%22">Cui J</searchLink>; MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, Innovation Center of the Sixth Affiliated Hospital, Center of Evolutionary Synthetic Biology, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.
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              Text: 2026 Apr
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