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CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia.

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Title: CCR4 expression defines a targetable subset of T-cell acute lymphoblastic leukemia.
Authors: Xu J; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Internal Medicine, Stanford University, Stanford, CA., McCoy M; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Martinez Z; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Sussman JH; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Gao D; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Vincent T; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Wang H; Department of Internal Medicine, Stanford University, Stanford, CA., Ma C; Department of Internal Medicine, Stanford University, Stanford, CA., Elghawy O; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Chen GM; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Yang AG; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Pölönen P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Natan K; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Shraim R; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Newman H; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Hofmann TJ; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Scoma S; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., DiNofia AM; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Hunger SP; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Yang JJ; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN., Bernt KM; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Hexner EO; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Grupp SA; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Watanabe K; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., June CH; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA., Tan K; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.; Center for Single Cell Biology, Children's Hospital of Philadelphia, Philadelphia, PA., Teachey DT; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA., Diorio C; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
Source: Blood advances [Blood Adv] 2026 Apr 28; Vol. 10 (8), pp. 2676-2686.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Internal Medicine, Stanford University, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22McCoy+M%22">McCoy M</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Martinez+Z%22">Martinez Z</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Sussman+JH%22">Sussman JH</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Gao+D%22">Gao D</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Vincent+T%22">Vincent T</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Internal Medicine, Stanford University, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Department of Internal Medicine, Stanford University, Stanford, CA.<br /><searchLink fieldCode="AU" term="%22Elghawy+O%22">Elghawy O</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Chen+GM%22">Chen GM</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Yang+AG%22">Yang AG</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Pölönen+P%22">Pölönen P</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Natan+K%22">Natan K</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Shraim+R%22">Shraim R</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Newman+H%22">Newman H</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hofmann+TJ%22">Hofmann TJ</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Scoma+S%22">Scoma S</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22DiNofia+AM%22">DiNofia AM</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hunger+SP%22">Hunger SP</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Yang+JJ%22">Yang JJ</searchLink>; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Mullighan+CG%22">Mullighan CG</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Bernt+KM%22">Bernt KM</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Hexner+EO%22">Hexner EO</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Grupp+SA%22">Grupp SA</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Watanabe+K%22">Watanabe K</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Tan+K%22">Tan K</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.; Center for Single Cell Biology, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Teachey+DT%22">Teachey DT</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Diorio+C%22">Diorio C</searchLink>; Department of Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA.
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