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Lumbrokinase modulates tissue plasminogen activator and alleviates behavioral and cognitive deficits in mice with chronic social defeat stress.

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Title: Lumbrokinase modulates tissue plasminogen activator and alleviates behavioral and cognitive deficits in mice with chronic social defeat stress.
Authors: Charoensaensuk V; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan., Huang BR; Department of Neurosurgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan., Huang SS; Department of Pharmacology and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan., Tsai CF; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan., Chen YC; Institute of Translational Medicine and New Drug Development, China Medical University, Taichung, Taiwan., Lin CY; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan., Lin C; Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan., Cheng HT; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Department of Surgery, China Medical University Hospital, Taichung, Taiwan., Chen CW; Institute of Translational Medicine and New Drug Development, China Medical University, Taichung, Taiwan., Wang YW; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan., Yang LY; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan; Laboratory for Neural Repair, China Medical University Hospital, Taichung, Taiwan., Yeh WL; Institute of Translational Medicine and New Drug Development, China Medical University, Taichung, Taiwan; Department of Biochemistry, School of Medicine, China Medical University, Taiwan. Electronic address: wlyeh@mail.cmu.edu.tw., Lu DY; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Office of Research and Development, Asia University, Taichung, Taiwan. Electronic address: dahyuu@mail.cmu.edu.tw.
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2026 Mar; Vol. 196, pp. 119024. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lumbrokinase modulates tissue plasminogen activator and alleviates behavioral and cognitive deficits in mice with chronic social defeat stress.
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  Data: <searchLink fieldCode="AU" term="%22Charoensaensuk+V%22">Charoensaensuk V</searchLink>; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+BR%22">Huang BR</searchLink>; Department of Neurosurgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SS%22">Huang SS</searchLink>; Department of Pharmacology and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CF%22">Tsai CF</searchLink>; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CY%22">Lin CY</searchLink>; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+C%22">Lin C</searchLink>; Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+HT%22">Cheng HT</searchLink>; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Department of Surgery, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CW%22">Chen CW</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YW%22">Wang YW</searchLink>; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+LY%22">Yang LY</searchLink>; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan; Laboratory for Neural Repair, China Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+WL%22">Yeh WL</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, Taichung, Taiwan; Department of Biochemistry, School of Medicine, China Medical University, Taiwan. Electronic address: wlyeh@mail.cmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Lu+DY%22">Lu DY</searchLink>; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan; Office of Research and Development, Asia University, Taichung, Taiwan. Electronic address: dahyuu@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%228213295%22">Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</searchLink> [Biomed Pharmacother] 2026 Mar; Vol. 196, pp. 119024. <i>Date of Electronic Publication: </i>2026 Feb 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>8213295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1950-6007 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207533322%22">07533322 </searchLink><i>NLM ISO Abbreviation: </i>Biomed Pharmacother <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.biopha.2026.119024
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        Text: English
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              Text: 2026 Mar
              Type: published
              Y: 2026
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