Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.

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Title: Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.
Authors: Kim PG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Center, Mass General Research Institute, Massachusetts General Hospital, Boston, MA, USA., Hergott CB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Miller AP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Deik A; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Boileau M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bullock K; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Pierce KA; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Choy AH; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Shin W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., McConkey M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Loke J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; CRUK Manchester Institute, University of Manchester, Manchester, UK., Ryback BA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Trinh MN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rutter JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Yue H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Yoon H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Park P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Vander Heiden MG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Clish C; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: benjamin_ebert@dfci.harvard.edu.
Source: Cell chemical biology [Cell Chem Biol] 2026 Feb 19; Vol. 33 (2), pp. 183-197.e9. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2451-9448
DOI:10.1016/j.chembiol.2026.01.006