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Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.

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Title: Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.
Authors: Kim PG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Center, Mass General Research Institute, Massachusetts General Hospital, Boston, MA, USA., Hergott CB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Miller AP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Deik A; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Boileau M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Bullock K; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Pierce KA; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Choy AH; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Shin W; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., McConkey M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Loke J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; CRUK Manchester Institute, University of Manchester, Manchester, UK., Ryback BA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Trinh MN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rutter JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Yue H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Yoon H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Park P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Roy Burman SS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Vander Heiden MG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Clish C; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: benjamin_ebert@dfci.harvard.edu.
Source: Cell chemical biology [Cell Chem Biol] 2026 Feb 19; Vol. 33 (2), pp. 183-197.e9. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kim+PG%22">Kim PG</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Center, Mass General Research Institute, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hergott+CB%22">Hergott CB</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+AP%22">Miller AP</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Deik+A%22">Deik A</searchLink>; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boileau+M%22">Boileau M</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bullock+K%22">Bullock K</searchLink>; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pierce+KA%22">Pierce KA</searchLink>; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Choy+AH%22">Choy AH</searchLink>; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shin+W%22">Shin W</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McConkey+M%22">McConkey M</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Loke+J%22">Loke J</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; CRUK Manchester Institute, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Ryback+BA%22">Ryback BA</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Trinh+MN%22">Trinh MN</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+JC%22">Rutter JC</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yue+H%22">Yue H</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yoon+H%22">Yoon H</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Park+P%22">Park P</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roy+Burman+SS%22">Roy Burman SS</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+MG%22">Vander Heiden MG</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+ES%22">Fischer ES</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Armstrong+SA%22">Armstrong SA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Clish+C%22">Clish C</searchLink>; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: benjamin_ebert@dfci.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%22101676030%22">Cell chemical biology</searchLink> [Cell Chem Biol] 2026 Feb 19; Vol. 33 (2), pp. 183-197.e9. <i>Date of Electronic Publication: </i>2026 Feb 10.
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