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Surfactant nebulization in severe COVID-19: Tracheal aspirate phospholipid turnover and metabolism.

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Title: Surfactant nebulization in severe COVID-19: Tracheal aspirate phospholipid turnover and metabolism.
Authors: Postle AD; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; Intergrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK. Electronic address: adp@soton.ac.uk., Clark HW; EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London Hospital, Room 343, Medical School Building, 74, Huntley Street, London, WC1E 6AU, UK; NIHR University College London Hospital Biomedical Research Centre, Infection and Immunity Theme, 149 Tottenham Court Road, London, W1T 7DN, UK., Fink J; Aerogen Pharma Corporation, 1660 S. Amphlett Blvd, Suite 360, San Mateo, CA, 94402, USA., Madsen J; EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London Hospital, Room 343, Medical School Building, 74, Huntley Street, London, WC1E 6AU, UK., Koster G; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK., Panchal M; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK., Matthews L; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK., Berry L; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK., Djukanovic R; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK., Brealey D; Division of Critical Care and NIHR University College London Hospitals Biomedical Research Centre, University College Hospitals London, 235 Euston Road, London, NW1 2BU, UK., Grocott MPW; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; Intergrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK., Dushianthan A; Intergrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.
Source: Biochimica et biophysica acta. Molecular and cell biology of lipids [Biochim Biophys Acta Mol Cell Biol Lipids] 2026 Apr; Vol. 1871 (3), pp. 159731. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731727 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2618 (Electronic) Linking ISSN: 13881981 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Biol Lipids Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Postle+AD%22">Postle AD</searchLink>; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; Intergrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK. Electronic address: adp@soton.ac.uk.<br /><searchLink fieldCode="AU" term="%22Clark+HW%22">Clark HW</searchLink>; EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London Hospital, Room 343, Medical School Building, 74, Huntley Street, London, WC1E 6AU, UK; NIHR University College London Hospital Biomedical Research Centre, Infection and Immunity Theme, 149 Tottenham Court Road, London, W1T 7DN, UK.<br /><searchLink fieldCode="AU" term="%22Fink+J%22">Fink J</searchLink>; Aerogen Pharma Corporation, 1660 S. Amphlett Blvd, Suite 360, San Mateo, CA, 94402, USA.<br /><searchLink fieldCode="AU" term="%22Madsen+J%22">Madsen J</searchLink>; EGA Institute for Women's Health, Faculty of Population Health Sciences, University College London Hospital, Room 343, Medical School Building, 74, Huntley Street, London, WC1E 6AU, UK.<br /><searchLink fieldCode="AU" term="%22Koster+G%22">Koster G</searchLink>; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.<br /><searchLink fieldCode="AU" term="%22Panchal+M%22">Panchal M</searchLink>; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+L%22">Matthews L</searchLink>; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.<br /><searchLink fieldCode="AU" term="%22Berry+L%22">Berry L</searchLink>; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.<br /><searchLink fieldCode="AU" term="%22Djukanovic+R%22">Djukanovic R</searchLink>; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.<br /><searchLink fieldCode="AU" term="%22Brealey+D%22">Brealey D</searchLink>; Division of Critical Care and NIHR University College London Hospitals Biomedical Research Centre, University College Hospitals London, 235 Euston Road, London, NW1 2BU, UK.<br /><searchLink fieldCode="AU" term="%22Grocott+MPW%22">Grocott MPW</searchLink>; Clinical and Experimental Sciences, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK; Intergrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.<br /><searchLink fieldCode="AU" term="%22Dushianthan+A%22">Dushianthan A</searchLink>; Intergrative Physiology and Critical Illness Group, Faculty of Medicine, University of Southampton, SO16 6YD, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre and Critical Care/Anaesthesia and Perioperative Medicine Research Unit, University Hospital Southampton National Health System Foundation Trust, Southampton, SO16 6YD, UK.
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