A tumor DNA-Methylome derived signature of Hypoxia Identifies HPV-negative head and neck cancer patients at risk for distant metastasis after postoperative radiochemotherapy (PORT-C).
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| Title: | A tumor DNA-Methylome derived signature of Hypoxia Identifies HPV-negative head and neck cancer patients at risk for distant metastasis after postoperative radiochemotherapy (PORT-C). |
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| Authors: | Tawk B; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: b.tawk@dkfz.de., Halec G; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Rein K; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Schwager C; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Knoll M; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Wirkner U; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Held T; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Weykamp F; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Liermann J; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Hoerner-Rieber J; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Kurth I; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Division of Radiooncology and Radiobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Balermpas P; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), partner site, Frankfurt, Germany; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland., Rödel C; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, Frankfurt, Germany., Fleischmann M; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, Frankfurt, Germany., Linge A; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany., Löck S; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany., Lohaus F; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany., Tinhofer I; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Berlin, Heidelberg, Germany; Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany., Krause M; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany., Stuschke M; Department of Radiotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Freiburg, Heidelberg, Germany., Grosu AL; Department of Radiation Oncology, University of Freiburg, Freiburg, Germany; German Cancer Research Center (DKFZ), Germany, German Cancer Consortium (DKTK), partner site Tuebingen, Heidelberg, Germany., Schäfer H; Department of Radiation Oncology, University of Freiburg, Freiburg, Germany; German Cancer Research Center (DKFZ), Germany, German Cancer Consortium (DKTK), partner site Tuebingen, Heidelberg, Germany., Zips D; Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Essen, Heidelberg, Germany; Department of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls Universität Tübingen, Germany; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Munich, Heidelberg, Germany., Combs SE; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Munich, Heidelberg, Germany; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany., Belka C; Department of Radiation Oncology, Technische Universität München, Munich, Germany; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Stenzinger A; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Herold-Mende C; Division of Experimental Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany., Baumann M; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Division of Radiooncology and Radiobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schirmacher P; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany., Debus J; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Abdollahi A; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany. |
| Source: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2026 Apr; Vol. 217, pp. 111433. Date of Electronic Publication: 2026 Feb 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41672251 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A tumor DNA-Methylome derived signature of Hypoxia Identifies HPV-negative head and neck cancer patients at risk for distant metastasis after postoperative radiochemotherapy (PORT-C). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tawk+B%22">Tawk B</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: b.tawk@dkfz.de.<br /><searchLink fieldCode="AU" term="%22Halec+G%22">Halec G</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rein+K%22">Rein K</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwager+C%22">Schwager C</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Knoll+M%22">Knoll M</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wirkner+U%22">Wirkner U</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Held+T%22">Held T</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weykamp+F%22">Weykamp F</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Liermann+J%22">Liermann J</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoerner-Rieber+J%22">Hoerner-Rieber J</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kurth+I%22">Kurth I</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Division of Radiooncology and Radiobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Balermpas+P%22">Balermpas P</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), partner site, Frankfurt, Germany; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rödel+C%22">Rödel C</searchLink>; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Fleischmann+M%22">Fleischmann M</searchLink>; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Linge+A%22">Linge A</searchLink>; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Löck+S%22">Löck S</searchLink>; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Lohaus+F%22">Lohaus F</searchLink>; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Tinhofer+I%22">Tinhofer I</searchLink>; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Berlin, Heidelberg, Germany; Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Krause+M%22">Krause M</searchLink>; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Dresden, Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz Association and Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Stuschke+M%22">Stuschke M</searchLink>; Department of Radiotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Freiburg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Grosu+AL%22">Grosu AL</searchLink>; Department of Radiation Oncology, University of Freiburg, Freiburg, Germany; German Cancer Research Center (DKFZ), Germany, German Cancer Consortium (DKTK), partner site Tuebingen, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schäfer+H%22">Schäfer H</searchLink>; Department of Radiation Oncology, University of Freiburg, Freiburg, Germany; German Cancer Research Center (DKFZ), Germany, German Cancer Consortium (DKTK), partner site Tuebingen, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zips+D%22">Zips D</searchLink>; Department of Radiooncology and Radiotherapy, Charité University Hospital, Berlin, Germany; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Essen, Heidelberg, Germany; Department of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls Universität Tübingen, Germany; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Munich, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Combs+SE%22">Combs SE</searchLink>; German Cancer Research Center (DKFZ), Germany, and German Cancer Consortium (DKTK), partner site Munich, Heidelberg, Germany; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Belka+C%22">Belka C</searchLink>; Department of Radiation Oncology, Technische Universität München, Munich, Germany; Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stenzinger+A%22">Stenzinger A</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Herold-Mende+C%22">Herold-Mende C</searchLink>; Division of Experimental Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Baumann+M%22">Baumann M</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Division of Radiooncology and Radiobiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden - Rossendorf, Dresden, Germany; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schirmacher+P%22">Schirmacher P</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Department of Radiation Oncology, University Hospital Ludwig-Maximilians-University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Debus+J%22">Debus J</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Abdollahi+A%22">Abdollahi A</searchLink>; German Cancer Research Center (DKFZ), Germany and German Cancer Consortium (DKTK), Core Center Heidelberg, Germany; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, Department of Radiation Oncology, Heidelberg Faculty of Medicine (MFHD) and Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228407192%22">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology</searchLink> [Radiother Oncol] 2026 Apr; Vol. 217, pp. 111433. <i>Date of Electronic Publication: </i>2026 Feb 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers%22">Elsevier Scientific Publishers </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>8407192 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0887 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201678140%22">01678140 </searchLink><i>NLM ISO Abbreviation: </i>Radiother Oncol <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.radonc.2026.111433 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 111433 Titles: – TitleFull: A tumor DNA-Methylome derived signature of Hypoxia Identifies HPV-negative head and neck cancer patients at risk for distant metastasis after postoperative radiochemotherapy (PORT-C). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tawk B – PersonEntity: Name: NameFull: Halec G – PersonEntity: Name: NameFull: Rein K – PersonEntity: Name: NameFull: Schwager C – PersonEntity: Name: NameFull: Knoll M – PersonEntity: Name: NameFull: Wirkner U – PersonEntity: Name: NameFull: Held T – PersonEntity: Name: NameFull: Weykamp F – PersonEntity: Name: NameFull: Liermann J – PersonEntity: Name: NameFull: Hoerner-Rieber J – PersonEntity: Name: NameFull: Kurth I – PersonEntity: Name: NameFull: Balermpas P – PersonEntity: Name: NameFull: Rödel C – PersonEntity: Name: NameFull: Fleischmann M – PersonEntity: Name: NameFull: Linge A – PersonEntity: Name: NameFull: Löck S – PersonEntity: Name: NameFull: Lohaus F – PersonEntity: Name: NameFull: Tinhofer I – PersonEntity: Name: NameFull: Krause M – PersonEntity: Name: NameFull: Stuschke M – PersonEntity: Name: NameFull: Grosu AL – PersonEntity: Name: NameFull: Schäfer H – PersonEntity: Name: NameFull: Zips D – PersonEntity: Name: NameFull: Combs SE – PersonEntity: Name: NameFull: Belka C – PersonEntity: Name: NameFull: Stenzinger A – PersonEntity: Name: NameFull: Herold-Mende C – PersonEntity: Name: NameFull: Baumann M – PersonEntity: Name: NameFull: Schirmacher P – PersonEntity: Name: NameFull: Debus J – PersonEntity: Name: NameFull: Abdollahi A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2026 Apr Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1879-0887 Numbering: – Type: volume Value: 217 Titles: – TitleFull: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Type: main |
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