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Protective effect of scorpion-venom heat-resistant peptide (SVHRSP) against depression associated with Parkinson's disease via suppression of CREB-Akt pathway-mediated inflammation.

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Title: Protective effect of scorpion-venom heat-resistant peptide (SVHRSP) against depression associated with Parkinson's disease via suppression of CREB-Akt pathway-mediated inflammation.
Authors: Iqbal MK; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning, China., Supratik K; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Khan B; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Ahmad K; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Ge Y; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Ai Y; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Shaikh S; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Khalil MI; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Guo SY; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Sui AR; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Zhao YF; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Li QF; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Wang B; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China., Zhao CL; Department of Critical Care Medicine, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, Liaoning, China., Li S; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning, China.
Source: British journal of pharmacology [Br J Pharmacol] 2026 Jun; Vol. 183 (11), pp. 2820-2836. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protective effect of scorpion-venom heat-resistant peptide (SVHRSP) against depression associated with Parkinson's disease via suppression of CREB-Akt pathway-mediated inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Iqbal+MK%22">Iqbal MK</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Supratik+K%22">Supratik K</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Khan+B%22">Khan B</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Ahmad+K%22">Ahmad K</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Ge+Y%22">Ge Y</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Ai+Y%22">Ai Y</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Shaikh+S%22">Shaikh S</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Khalil+MI%22">Khalil MI</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Guo+SY%22">Guo SY</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Sui+AR%22">Sui AR</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Zhao+YF%22">Zhao YF</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+QF%22">Li QF</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Zhao+CL%22">Zhao CL</searchLink>; Department of Critical Care Medicine, Affiliated Dalian Friendship Hospital of Dalian Medical University, Dalian, Liaoning, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Physiology, College of Basic Medical Sciences, Liaoning Provincial Key Laboratory of Cerebral Diseases, Dalian Medical University, Dalian, Liaoning, China.; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, Liaoning, China.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2026 Jun; Vol. 183 (11), pp. 2820-2836. <i>Date of Electronic Publication: </i>2026 Feb 11.
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        Value: 10.1111/bph.70364
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        Text: English
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              Text: 2026 Jun
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