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CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.

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Title: CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.
Authors: Shi H; Department of Pharmacology, University of Washington, Seattle, WA, USA., Wang X; Department of Physiology and Biophysics, University of California, Irvine, CA, USA., Yu C; Department of Physiology and Biophysics, University of California, Irvine, CA, USA., Mao H; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Jiao F; Department of Physiology and Biophysics, University of California, Irvine, CA, USA., Braitbard M; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Shor B; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Zhang Z; Department of Biochemistry, University of Washington, Seattle, WA, USA., Hinds TR; Department of Pharmacology, University of Washington, Seattle, WA, USA., Cao S; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Fan E; Department of Biochemistry, University of Washington, Seattle, WA, USA., Schneidman-Duhovny D; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel., Huang L; Department of Physiology and Biophysics, University of California, Irvine, CA, USA. lanhuang@uci.edu., Zheng N; Department of Pharmacology, University of Washington, Seattle, WA, USA. nzheng@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. nzheng@uw.edu.
Source: Nature [Nature] 2026 Apr; Vol. 652 (8112), pp. 1375-1383. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.
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  Data: <searchLink fieldCode="AU" term="%22Shi+H%22">Shi H</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mao+H%22">Mao H</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+F%22">Jiao F</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Braitbard+M%22">Braitbard M</searchLink>; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Shor+B%22">Shor B</searchLink>; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hinds+TR%22">Hinds TR</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+S%22">Cao S</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Fan+E%22">Fan E</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Schneidman-Duhovny+D%22">Schneidman-Duhovny D</searchLink>; The Rachel and Selim Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, CA, USA. lanhuang@uci.edu.<br /><searchLink fieldCode="AU" term="%22Zheng+N%22">Zheng N</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA. nzheng@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. nzheng@uw.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Apr; Vol. 652 (8112), pp. 1375-1383. <i>Date of Electronic Publication: </i>2026 Feb 11.
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