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Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells.

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Title: Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells.
Authors: Zhang J; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China., Fu H; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Liu S; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Xie J; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Zhao S; Emergency Department, No. 73 Group Army Hospital of the PLA Army, Xiamen, Fujian, 361000, China., Wang X; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Wang Q; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Hu S; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Zhao P; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China., Chen J; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. 253192178@qq.com., Li J; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. doctorljj@126.com., Yin W; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. xjyyyw@126.com.
Source: Cell biology and toxicology [Cell Biol Toxicol] 2026 Feb 11; Vol. 42 (1). Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell RNA-Seq reveals transcriptional heterogeneity in sepsis and down-regulation of SNHG5/miR-324-5p/CDK16 axis in T cells.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.; Department of Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.<br /><searchLink fieldCode="AU" term="%22Fu+H%22">Fu H</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; Emergency Department, No. 73 Group Army Hospital of the PLA Army, Xiamen, Fujian, 361000, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Hu+S%22">Hu S</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. 253192178@qq.com.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. doctorljj@126.com.<br /><searchLink fieldCode="AU" term="%22Yin+W%22">Yin W</searchLink>; Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. xjyyyw@126.com.
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  Data: <searchLink fieldCode="JN" term="%228506639%22">Cell biology and toxicology</searchLink> [Cell Biol Toxicol] 2026 Feb 11; Vol. 42 (1). <i>Date of Electronic Publication: </i>2026 Feb 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>8506639 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-6822 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207422091%22">07422091 </searchLink><i>NLM ISO Abbreviation: </i>Cell Biol Toxicol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10565-026-10136-9
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              Text: 2026 Feb 11
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