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The effect of exogenous ketone monoester supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline: study protocol for a randomized crossover trial.

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Title: The effect of exogenous ketone monoester supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline: study protocol for a randomized crossover trial.
Authors: Danielli E; Department of Kinesiology, McMaster University, Hamilton, Canada., Rourke AJ; Department of Kinesiology, McMaster University, Hamilton, Canada., Coombs GB; School of Psychology & Sport Science, Bangor University, Bangor, Wales., Noseworthy MD; Department of Electrical and Computer Engineering, McMaster University, Hamilton, Canada.; GERAS Centre for Aging Research, McMaster University, Hamilton, Canada., Mbuagbaw L; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada., Al-Khazraji BK; Department of Kinesiology, McMaster University, Hamilton, Canada., Papaioannou A; GERAS Centre for Aging Research, McMaster University, Hamilton, Canada.; Division of Geriatric Medicine & Rheumatology, Faculty of Medicine, McMaster University, Hamilton, Canada., Krumm S; Memory Clinic, Felix Platter Hospital, Basel, Switzerland., Walsh JJ; Department of Kinesiology, McMaster University, Hamilton, Canada. walshj18@mcmaster.ca.; GERAS Centre for Aging Research, McMaster University, Hamilton, Canada. walshj18@mcmaster.ca.
Source: Trials [Trials] 2026 Feb 11; Vol. 27 (1). Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The effect of exogenous ketone monoester supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline: study protocol for a randomized crossover trial.
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  Data: <searchLink fieldCode="AU" term="%22Danielli+E%22">Danielli E</searchLink>; Department of Kinesiology, McMaster University, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Rourke+AJ%22">Rourke AJ</searchLink>; Department of Kinesiology, McMaster University, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Coombs+GB%22">Coombs GB</searchLink>; School of Psychology & Sport Science, Bangor University, Bangor, Wales.<br /><searchLink fieldCode="AU" term="%22Noseworthy+MD%22">Noseworthy MD</searchLink>; Department of Electrical and Computer Engineering, McMaster University, Hamilton, Canada.; GERAS Centre for Aging Research, McMaster University, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Mbuagbaw+L%22">Mbuagbaw L</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Al-Khazraji+BK%22">Al-Khazraji BK</searchLink>; Department of Kinesiology, McMaster University, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Papaioannou+A%22">Papaioannou A</searchLink>; GERAS Centre for Aging Research, McMaster University, Hamilton, Canada.; Division of Geriatric Medicine & Rheumatology, Faculty of Medicine, McMaster University, Hamilton, Canada.<br /><searchLink fieldCode="AU" term="%22Krumm+S%22">Krumm S</searchLink>; Memory Clinic, Felix Platter Hospital, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Walsh+JJ%22">Walsh JJ</searchLink>; Department of Kinesiology, McMaster University, Hamilton, Canada. walshj18@mcmaster.ca.; GERAS Centre for Aging Research, McMaster University, Hamilton, Canada. walshj18@mcmaster.ca.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13063-026-09487-9
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        Text: English
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      – TitleFull: The effect of exogenous ketone monoester supplementation on cerebral blood flow and functional brain characteristics in adults with subjective cognitive decline: study protocol for a randomized crossover trial.
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              Text: 2026 Feb 11
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