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Iron diminishes immunosuppressive macrophages and enhances anti-PD-1 immunotherapy in breast cancer models.

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Title: Iron diminishes immunosuppressive macrophages and enhances anti-PD-1 immunotherapy in breast cancer models.
Authors: Wang Q; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. qw25@iu.edu.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA. qw25@iu.edu., Adams EL; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA., Poole RA; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA., Soleimani T; IU Health Surgical Oncology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Wang GX; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Li H; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Capitano ML; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Masood A; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.; Computing, and Engineering, Luddy School of Informatics, Indiana University, Indianapolis, IN, 46202, USA., Abrams SI; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA., Lee KP; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA., Zhang S; Department of Biological Sciences, Mike and Josie Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, 75390, USA., Opyrchal M; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mopyrch@iu.edu.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA. mopyrch@iu.edu.
Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2026 Feb 12; Vol. 45 (1). Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. qw25@iu.edu.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA. qw25@iu.edu.<br /><searchLink fieldCode="AU" term="%22Adams+EL%22">Adams EL</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Poole+RA%22">Poole RA</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Soleimani+T%22">Soleimani T</searchLink>; IU Health Surgical Oncology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Wang+GX%22">Wang GX</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Capitano+ML%22">Capitano ML</searchLink>; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Masood+A%22">Masood A</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.; Computing, and Engineering, Luddy School of Informatics, Indiana University, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Abrams+SI%22">Abrams SI</searchLink>; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.<br /><searchLink fieldCode="AU" term="%22Lee+KP%22">Lee KP</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; Department of Biological Sciences, Mike and Josie Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA.; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Opyrchal+M%22">Opyrchal M</searchLink>; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mopyrch@iu.edu.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, 46202, USA. mopyrch@iu.edu.
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              Text: 2026 Feb 12
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