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Donor-matched iPSC model reveals context-dependent T2D genetic signals in fibro-adipogenic progenitors.

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Title: Donor-matched iPSC model reveals context-dependent T2D genetic signals in fibro-adipogenic progenitors.
Authors: Ventresca C; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Varshney A; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Orchard P; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Vu HTH; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Tsan YC; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Monteiro da Rocha A; Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA., Erdos MR; Molecular Genetics Section, NHGRI, NIH., Kinnunen L; work reported here performed during former affiliation at Finnish Institute for Health and Welfare, Helsinki, Finland.; Faculty of Medicine, Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Saramies J; South Karelia Social and Health Care District, Wellbeing services county of South Karelia, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland., Tuomilehto J; Department of Public Health, University of Helsinki, Helsinki, Finland., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Koistinen HA; work reported here performed during former affiliation at Finnish Institute for Health and Welfare, Helsinki, Finland.; Faculty of Medicine, Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Collins FS; Currently unaffiliated; NHGRI work reported here preceded retirement on March 1, 2025., Herron T; Greenstone Biosciences, Palo Alto, CA, USA., Bielas S; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Pediatrics, University of Michigan, Ann Arbor, MI, USA., Parker SCJ; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 06. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Donor-matched iPSC model reveals context-dependent T2D genetic signals in fibro-adipogenic progenitors.
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  Data: <searchLink fieldCode="AU" term="%22Ventresca+C%22">Ventresca C</searchLink>; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Varshney+A%22">Varshney A</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Orchard+P%22">Orchard P</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Vu+HTH%22">Vu HTH</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tsan+YC%22">Tsan YC</searchLink>; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Monteiro+da+Rocha+A%22">Monteiro da Rocha A</searchLink>; Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Erdos+MR%22">Erdos MR</searchLink>; Molecular Genetics Section, NHGRI, NIH.<br /><searchLink fieldCode="AU" term="%22Kinnunen+L%22">Kinnunen L</searchLink>; work reported here performed during former affiliation at Finnish Institute for Health and Welfare, Helsinki, Finland.; Faculty of Medicine, Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lakka+TA%22">Lakka TA</searchLink>; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Saramies+J%22">Saramies J</searchLink>; South Karelia Social and Health Care District, Wellbeing services county of South Karelia, Finland.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicine, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Tuomilehto+J%22">Tuomilehto J</searchLink>; Department of Public Health, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Mohlke+KL%22">Mohlke KL</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Scott+LJ%22">Scott LJ</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Koistinen+HA%22">Koistinen HA</searchLink>; work reported here performed during former affiliation at Finnish Institute for Health and Welfare, Helsinki, Finland.; Faculty of Medicine, Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Collins+FS%22">Collins FS</searchLink>; Currently unaffiliated; NHGRI work reported here preceded retirement on March 1, 2025.<br /><searchLink fieldCode="AU" term="%22Herron+T%22">Herron T</searchLink>; Greenstone Biosciences, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bielas+S%22">Bielas S</searchLink>; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Pediatrics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Parker+SCJ%22">Parker SCJ</searchLink>; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Lead contact.
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