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Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease.

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Title: Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease.
Authors: Chu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Key lab of Artificial Organs and Computational Medicine, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China., Wang J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yarbro JM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Chen PC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Shrestha HK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Sun H; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Niu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Harvey S; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wu Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Fu Y; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yuan ZF; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Tan H; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., High AA; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zhang A; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA., Wang X; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA., Lu M; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Sheppard H; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, Arizona 85351, United States., Beach TG; Banner Sun Health Research Institute, Sun City, Arizona 85351, United States., Yu G; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jiao Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 04. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Chu+M%22">Chu M</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Key lab of Artificial Organs and Computational Medicine, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, 310015, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Yarbro+JM%22">Yarbro JM</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Chen+PC%22">Chen PC</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+HK%22">Shrestha HK</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Niu+M%22">Niu M</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Harvey+S%22">Harvey S</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Fu+Y%22">Fu Y</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+ZF%22">Yuan ZF</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Tan+H%22">Tan H</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22High+AA%22">High AA</searchLink>; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.<br /><searchLink fieldCode="AU" term="%22Lu+M%22">Lu M</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Sheppard+H%22">Sheppard H</searchLink>; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Serrano+GE%22">Serrano GE</searchLink>; Banner Sun Health Research Institute, Sun City, Arizona 85351, United States.<br /><searchLink fieldCode="AU" term="%22Beach+TG%22">Beach TG</searchLink>; Banner Sun Health Research Institute, Sun City, Arizona 85351, United States.<br /><searchLink fieldCode="AU" term="%22Yu+G%22">Yu G</searchLink>; Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+Y%22">Jiao Y</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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