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IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis.

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Title: IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis.
Authors: Mela A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Brand A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Dovas A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Kanangat S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Kleinstein AC; Department of Neuroscience and Behavior, Barnard College, Columbia University, New York, NY, USA., Leskinen S; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Nguyen TT; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Gao Q; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Upadhyayula PS; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Guo J; Department of Psychiatry, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Gill B; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Stockwell BR; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Chemistry, Irving Institute for Cancer Dynamics, Data Science Institute, Columbia University, New York, NY, USA.; Department of Biological Sciences, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Digestive and Liver Disease Research Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 02. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis.
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  Data: <searchLink fieldCode="AU" term="%22Mela+A%22">Mela A</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Brand+A%22">Brand A</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mahajan+A%22">Mahajan A</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dovas+A%22">Dovas A</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Humala+N%22">Humala N</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kanangat+S%22">Kanangat S</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kleinstein+AC%22">Kleinstein AC</searchLink>; Department of Neuroscience and Behavior, Barnard College, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Leskinen+S%22">Leskinen S</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TT%22">Nguyen TT</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Upadhyayula+PS%22">Upadhyayula PS</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Department of Psychiatry, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gill+B%22">Gill B</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Siegelin+MD%22">Siegelin MD</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sims+PA%22">Sims PA</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stockwell+BR%22">Stockwell BR</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Chemistry, Irving Institute for Cancer Dynamics, Data Science Institute, Columbia University, New York, NY, USA.; Department of Biological Sciences, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Digestive and Liver Disease Research Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bruce+JN%22">Bruce JN</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Canoll+P%22">Canoll P</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Feb 02. <i>Date of Electronic Publication: </i>2026 Feb 02.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.01.30.702627
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