IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis.
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| Title: | IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis. |
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| Authors: | Mela A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Brand A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Dovas A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Kanangat S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Kleinstein AC; Department of Neuroscience and Behavior, Barnard College, Columbia University, New York, NY, USA., Leskinen S; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Nguyen TT; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Gao Q; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Upadhyayula PS; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Guo J; Department of Psychiatry, Columbia University, New York, NY, USA.; Department of Biomedical Engineering, Columbia University, New York, NY, USA., Gill B; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Sims PA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Stockwell BR; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Chemistry, Irving Institute for Cancer Dynamics, Data Science Institute, Columbia University, New York, NY, USA.; Department of Biological Sciences, Columbia University, New York, NY, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Digestive and Liver Disease Research Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 02. Date of Electronic Publication: 2026 Feb 02. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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