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Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.

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Title: Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.
Authors: Berico P; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Dunton C; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA., Almassalha L; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Evanston, IL 60611, USA., Flores-Yanke A; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Medina KI; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA., Acosta N; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA., Muijlwijk T; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA., Do C; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Lee S; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Edmiston SN; Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC.; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC., Corcoran DL; Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC.; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC., Reiner A; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kostrzewa C; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dorsey K; Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC.; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC., Ibrahim M; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA., Qui S; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA., Shen R; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Thomas NE; Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC.; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC., Lund AW; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA., Moshiri AS; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA., Osman I; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA., Aifantis I; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Skok JA; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Backman V; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA., Hernando E; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 20. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.
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  Data: <searchLink fieldCode="AU" term="%22Berico+P%22">Berico P</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dunton+C%22">Dunton C</searchLink>; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.<br /><searchLink fieldCode="AU" term="%22Almassalha+L%22">Almassalha L</searchLink>; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Evanston, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Flores-Yanke+A%22">Flores-Yanke A</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Medina+KI%22">Medina KI</searchLink>; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.<br /><searchLink fieldCode="AU" term="%22Acosta+N%22">Acosta N</searchLink>; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.<br /><searchLink fieldCode="AU" term="%22Muijlwijk+T%22">Muijlwijk T</searchLink>; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. 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Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Qui+S%22">Qui S</searchLink>; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shen+R%22">Shen R</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Thomas+NE%22">Thomas NE</searchLink>; Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC.; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Lund+AW%22">Lund AW</searchLink>; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Moshiri+AS%22">Moshiri AS</searchLink>; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Osman+I%22">Osman I</searchLink>; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Aifantis+I%22">Aifantis I</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Skok+JA%22">Skok JA</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Backman+V%22">Backman V</searchLink>; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.<br /><searchLink fieldCode="AU" term="%22Hernando+E%22">Hernando E</searchLink>; Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.; Interdisciplinary Melanoma Cooperative Group, Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.
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