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Applicability of mitotic figure counting by deep learning: a development and pan-cancer validation study.

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Title: Applicability of mitotic figure counting by deep learning: a development and pan-cancer validation study.
Authors: Kalsnes J; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Isaksen MX; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Julbø F; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Pradhan M; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Kleppe A; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Department of Informatics, University of Oslo, Norway.; Centre for Research-based Innovation Visual Intelligence, UiT The Arctic University of Norway, Tromsø, Norway., De Raedt S; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Skrede OJ; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Torheim T; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Nesheim JA; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Mohn HM; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Askautrud HA; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Cyll K; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Kildal W; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Rewcastle E; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway., Lillesand M; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway., Kvikstad V; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway., Janssen E; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway., Jones R; Department of Hepatobiliary Surgery, Liverpool University Hospitals NHS Foundation Trust, UK.; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK., Brustugun OT; Section of Oncology, Vestre Viken Hospital Trust, Drammen, Norway.; Institute of Clinical Medicine, University of Oslo, Norway., Brennhovd B; Department of Urology, Oslo University Hospital, Norway., Haug ES; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Department of Urology, Vestfold Hospital Trust, Tønsberg, Norway., Busund LR; Department of Medical Biology, UiT, The Arctic University of Norway, Tromsø, Norway.; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway., Richardsen E; Department of Medical Biology, UiT, The Arctic University of Norway, Tromsø, Norway.; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway., Andersen S; Department of Oncology, University Hospital of North Norway, Tromso, Norway.; Institute of Clinical Medicine, UiT, The Arctic University of Norway, Tromso, Norway., Dønnem T; Department of Oncology, University Hospital of North Norway, Tromso, Norway.; Institute of Clinical Medicine, UiT, The Arctic University of Norway, Tromso, Norway., Lindemann K; Institute of Clinical Medicine, University of Oslo, Norway.; Section for Gynecological Oncology, Department of Surgical Oncology, Oslo University Hospital, Norway., Kristensen G; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Section for Gynecological Oncology, Department of Surgical Oncology, Oslo University Hospital, Norway., Shepherd NA; Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital, UK., Novelli M; Research Department of Pathology, University College London Medical School, UK., Liestøl K; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Department of Informatics, University of Oslo, Norway., Kerr D; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, UK., Danielsen HE; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway., Hveem TS; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.
Source: FEBS open bio [FEBS Open Bio] 2026 Jul; Vol. 16 (7), pp. 1259-1270. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101580716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-5463 (Electronic) Linking ISSN: 22115463 NLM ISO Abbreviation: FEBS Open Bio Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kalsnes+J%22">Kalsnes J</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Isaksen+MX%22">Isaksen MX</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Julbø+F%22">Julbø F</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Pradhan+M%22">Pradhan M</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Kleppe+A%22">Kleppe A</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Department of Informatics, University of Oslo, Norway.; Centre for Research-based Innovation Visual Intelligence, UiT The Arctic University of Norway, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22De+Raedt+S%22">De Raedt S</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Skrede+OJ%22">Skrede OJ</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Torheim+T%22">Torheim T</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Nesheim+JA%22">Nesheim JA</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Mohn+HM%22">Mohn HM</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Askautrud+HA%22">Askautrud HA</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Cyll+K%22">Cyll K</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Kildal+W%22">Kildal W</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Rewcastle+E%22">Rewcastle E</searchLink>; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway.<br /><searchLink fieldCode="AU" term="%22Lillesand+M%22">Lillesand M</searchLink>; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway.<br /><searchLink fieldCode="AU" term="%22Kvikstad+V%22">Kvikstad V</searchLink>; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway.<br /><searchLink fieldCode="AU" term="%22Janssen+E%22">Janssen E</searchLink>; Department of Pathology, Stavanger University Hospital, Norway.; Department of Chemistry, Bioscience and Environmental Engineering, Stavanger University, Norway.<br /><searchLink fieldCode="AU" term="%22Jones+R%22">Jones R</searchLink>; Department of Hepatobiliary Surgery, Liverpool University Hospitals NHS Foundation Trust, UK.; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Brustugun+OT%22">Brustugun OT</searchLink>; Section of Oncology, Vestre Viken Hospital Trust, Drammen, Norway.; Institute of Clinical Medicine, University of Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Brennhovd+B%22">Brennhovd B</searchLink>; Department of Urology, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Haug+ES%22">Haug ES</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Department of Urology, Vestfold Hospital Trust, Tønsberg, Norway.<br /><searchLink fieldCode="AU" term="%22Busund+LR%22">Busund LR</searchLink>; Department of Medical Biology, UiT, The Arctic University of Norway, Tromsø, Norway.; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Richardsen+E%22">Richardsen E</searchLink>; Department of Medical Biology, UiT, The Arctic University of Norway, Tromsø, Norway.; Department of Clinical Pathology, University Hospital of North Norway, Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Andersen+S%22">Andersen S</searchLink>; Department of Oncology, University Hospital of North Norway, Tromso, Norway.; Institute of Clinical Medicine, UiT, The Arctic University of Norway, Tromso, Norway.<br /><searchLink fieldCode="AU" term="%22Dønnem+T%22">Dønnem T</searchLink>; Department of Oncology, University Hospital of North Norway, Tromso, Norway.; Institute of Clinical Medicine, UiT, The Arctic University of Norway, Tromso, Norway.<br /><searchLink fieldCode="AU" term="%22Lindemann+K%22">Lindemann K</searchLink>; Institute of Clinical Medicine, University of Oslo, Norway.; Section for Gynecological Oncology, Department of Surgical Oncology, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Kristensen+G%22">Kristensen G</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Section for Gynecological Oncology, Department of Surgical Oncology, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Shepherd+NA%22">Shepherd NA</searchLink>; Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital, UK.<br /><searchLink fieldCode="AU" term="%22Novelli+M%22">Novelli M</searchLink>; Research Department of Pathology, University College London Medical School, UK.<br /><searchLink fieldCode="AU" term="%22Liestøl+K%22">Liestøl K</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.; Department of Informatics, University of Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Kerr+D%22">Kerr D</searchLink>; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Danielsen+HE%22">Danielsen HE</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Hveem+TS%22">Hveem TS</searchLink>; Institute for Cancer Genetics and Informatics, Oslo University Hospital, Norway.
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  Data: <searchLink fieldCode="JN" term="%22101580716%22">FEBS open bio</searchLink> [FEBS Open Bio] 2026 Jul; Vol. 16 (7), pp. 1259-1270. <i>Date of Electronic Publication: </i>2026 Feb 12.
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