Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma.

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Title: Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma.
Authors: Werr L; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and.; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Boland J; Department of Experimental Pediatric Oncology and Hematology.; Mildred Scheel School of Oncology, Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany., Petersen J; Department of Experimental Pediatric Oncology and Hematology.; Koeln Fortune Program/Faculty of Medicine, University of Cologne, Cologne, Germany., Iglesias F; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Höppner S; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and.; Mildred Scheel School of Oncology, Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany., Bartenhagen C; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and., Rosswog C; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany., Hellmann AM; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany., Kahlert Y; Department of Experimental Pediatric Oncology and Hematology., Hemstedt N; Department of Experimental Pediatric Oncology and Hematology., Ibruli N; Department of Experimental Pediatric Oncology and Hematology., Dammert MA; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Cologne., Decarolis B; Department of Pediatric Oncology and Hematology, and., Werner JM; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Division of Oncology and Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Malchers F; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany., Schramm K; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Division of Pediatric Glioma Research (B360) and., Witt O; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases, Heidelberg, Germany., Beiske KH; Department of Pathology, Oslo University Hospital, Oslo, Norway., Rognlien AGW; Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Gunnes MW; Division of Pediatric and Adolescent Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Langenberg KP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, Netherlands., Molenaar J; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, Netherlands.; Department of Pharmaceutical Sciences, University Utrecht, Utrecht, Netherlands., Bernkopf M; St. Anna Children's Cancer Research Institute, Vienna, Austria., Taschner-Mandl S; St. Anna Children's Cancer Research Institute, Vienna, Austria., Hughes D; Division of Clinical Studies, The Institute of Cancer Research, Sutton, London, United Kingdom., George SL; Division of Clinical Studies, The Institute of Cancer Research, Sutton, London, United Kingdom.; The Francis Crick Institute, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, Sutton, London, United Kingdom., Chesler L; Division of Clinical Studies, The Institute of Cancer Research, Sutton, London, United Kingdom., Schulte JH; University Children's Hospital, Eberhard Karls University, Abteilung I, Tuebingen, Germany., Barone G; Great Ormond Street Hospital, London, United Kingdom., Capasso M; Department of Molecular Medicine and Medical Biotechnology, University of Naples 'Federico II,' Naples, Italy.; CEINGE Biotecnologie Avanzate, Napoli, Italy., Surrey LF; Division of Genomic Diagnostics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pathology and Laboratory Medicine, and., Bagatell R; Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Masliah-Planchon J; Oncogenetic lab, Institute Curie, Paris, France., Schleiermacher G; Recherche Translationelle en Oncologie Pédiatrique; INSERM U830, and SIREDO Integrated Pediatric Oncology Center, PSL Research University, Institut Curie, Paris, France., Grüll H; Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany., Westermann F; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Division of Neuroblastoma Genomics, DFKZ, Heidelberg, Germany., Schultheis AM; Institute of Pathology, Faculty of Medicine and University Hospital Cologne., Büttner R; Institute of Pathology, Faculty of Medicine and University Hospital Cologne., Henssen AG; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; DKTK, Partner Site Berlin, and DKFZ, Heidelberg, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Technology Platform Electron Microscopy, Berlin, Germany.; Experimental and Clinical Research Center of the MDC and Charité Berlin, Berlin, Germany., Eggert A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Peifer M; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Cologne, Germany., Shukla NN; Koeln Fortune Program/Faculty of Medicine, University of Cologne, Cologne, Germany., Simon T; Department of Pediatric Oncology and Hematology, and., Hero B; Department of Pediatric Oncology and Hematology, and., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, DKTK, partner site Essen, Essen, Germany., Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Cologne., Fischer M; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Feb 12; Vol. 136 (7). Date of Electronic Publication: 2026 Feb 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
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  Data: Mutated FGFR1 is an oncogenic driver and therapeutic target in high-risk neuroblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Werr+L%22">Werr L</searchLink>; Department of Experimental Pediatric Oncology and Hematology.; Center for Molecular Medicine Cologne and Department of Experimental Pediatric Oncology, Medical Faculty, and.; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Boland+J%22">Boland J</searchLink>; Department of Experimental Pediatric Oncology and Hematology.; Mildred Scheel School of Oncology, Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Petersen+J%22">Petersen J</searchLink>; Department of Experimental Pediatric Oncology and Hematology.; Koeln Fortune Program/Faculty of Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Iglesias+F%22">Iglesias F</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Höppner+S%22">Höppner S</searchLink>; 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St. Anna Children's Cancer Research Institute, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Taschner-Mandl+S%22">Taschner-Mandl S</searchLink>; St. Anna Children's Cancer Research Institute, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hughes+D%22">Hughes D</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, Sutton, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22George+SL%22">George SL</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, Sutton, London, United Kingdom.; The Francis Crick Institute, London, United Kingdom.; Children and Young People's Unit, The Royal Marsden Hospital, Sutton, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chesler+L%22">Chesler L</searchLink>; Division of Clinical Studies, The Institute of Cancer Research, Sutton, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schulte+JH%22">Schulte JH</searchLink>; University Children's Hospital, Eberhard Karls University, Abteilung I, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Barone+G%22">Barone G</searchLink>; 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Recherche Translationelle en Oncologie Pédiatrique; INSERM U830, and SIREDO Integrated Pediatric Oncology Center, PSL Research University, Institut Curie, Paris, France.<br /><searchLink fieldCode="AU" term="%22Grüll+H%22">Grüll H</searchLink>; Faculty of Medicine and University Hospital of Cologne, Institute of Diagnostic and Interventional Radiology, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Westermann+F%22">Westermann F</searchLink>; Hopp Children's Cancer Center Heidelberg, Heidelberg, Germany.; Division of Neuroblastoma Genomics, DFKZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schultheis+AM%22">Schultheis AM</searchLink>; Institute of Pathology, Faculty of Medicine and University Hospital Cologne.<br /><searchLink fieldCode="AU" term="%22Büttner+R%22">Büttner R</searchLink>; Institute of Pathology, Faculty of Medicine and University Hospital Cologne.<br /><searchLink fieldCode="AU" term="%22Henssen+AG%22">Henssen AG</searchLink>; 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