ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation.
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| Title: | ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation. |
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| Authors: | Dhaliwal NK; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Weng OY; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Tian A; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Aggarwal A; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Ahmed M; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Sun G; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Bhattacharya A; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Choi WWY; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Nishimura H; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Chakraborty P; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Dong X; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China., Wu Y; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Wang LY; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada., Parada LF; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York NY 10065.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Muffat J; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Li Y; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Feb 17; Vol. 123 (7), pp. e2523367123. Date of Electronic Publication: 2026 Feb 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41678301 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Dhaliwal+NK%22">Dhaliwal NK</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Weng+OY%22">Weng OY</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Tian+A%22">Tian A</searchLink>; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Aggarwal+A%22">Aggarwal A</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmed+M%22">Ahmed M</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Sun+G%22">Sun G</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Bhattacharya+A%22">Bhattacharya A</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Choi+WWY%22">Choi WWY</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Nishimura+H%22">Nishimura H</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Chakraborty+P%22">Chakraborty P</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.<br /><searchLink fieldCode="AU" term="%22Wilson+MD%22">Wilson MD</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+LY%22">Wang LY</searchLink>; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Parada+LF%22">Parada LF</searchLink>; Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York NY 10065.; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Muffat+J%22">Muffat J</searchLink>; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Program in Developmental, Stem Cell and Cancer Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Feb 17; Vol. 123 (7), pp. e2523367123. <i>Date of Electronic Publication: </i>2026 Feb 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41678301 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2523367123 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e2523367123 Titles: – TitleFull: ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dhaliwal NK – PersonEntity: Name: NameFull: Weng OY – PersonEntity: Name: NameFull: Tian A – PersonEntity: Name: NameFull: Aggarwal A – PersonEntity: Name: NameFull: Ahmed M – PersonEntity: Name: NameFull: Sun G – PersonEntity: Name: NameFull: Bhattacharya A – PersonEntity: Name: NameFull: Choi WWY – PersonEntity: Name: NameFull: Nishimura H – PersonEntity: Name: NameFull: Chakraborty P – PersonEntity: Name: NameFull: Dong X – PersonEntity: Name: NameFull: Wu Y – PersonEntity: Name: NameFull: Wilson MD – PersonEntity: Name: NameFull: Wang LY – PersonEntity: Name: NameFull: Parada LF – PersonEntity: Name: NameFull: Muffat J – PersonEntity: Name: NameFull: Li Y IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 02 Text: 2026 Feb 17 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 123 – Type: issue Value: 7 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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