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Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.

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Title: Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.
Authors: Arafa D; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK., van de Korput J; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Braaker PN; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK., Higgins KP; Department of Axonal Signalling, Netherlands Institute for Neurosciences (NIN), Royal Netherlands Academy for Arts and Sciences (KNAW), Amsterdam, Netherlands.; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., Meijns NRC; Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.; MS Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands., Marshall-Phelps KLH; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK., Meng J; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK., Soong D; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; Zebrafish Imaging and Screening Facility, University of Edinburgh, Edinburgh, UK., Scalia E; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK., Lathem K; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Keatinge M; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK., Richmond C; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK., Klingseisen A; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Main M; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Neely SA; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK., Hampton DW; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK., Duncan GJ; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA., Schenk GJ; Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.; MS Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands., Groot ML; Faculty of Science, Department of Physics, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Chandran S; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK., Emery B; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA., Luchicchi A; Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.; MS Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands., Kole MHP; Department of Axonal Signalling, Netherlands Institute for Neurosciences (NIN), Royal Netherlands Academy for Arts and Sciences (KNAW), Amsterdam, Netherlands.; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands., Williams AC; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Lyons DA; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; Zebrafish Imaging and Screening Facility, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK.
Source: Science (New York, N.Y.) [Science] 2026 Feb 12; Vol. 391 (6786), pp. eadr4661. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.
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  Data: <searchLink fieldCode="AU" term="%22Arafa+D%22">Arafa D</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22van+de+Korput+J%22">van de Korput J</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Braaker+PN%22">Braaker PN</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Higgins+KP%22">Higgins KP</searchLink>; Department of Axonal Signalling, Netherlands Institute for Neurosciences (NIN), Royal Netherlands Academy for Arts and Sciences (KNAW), Amsterdam, Netherlands.; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Meijns+NRC%22">Meijns NRC</searchLink>; Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.; MS Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Marshall-Phelps+KLH%22">Marshall-Phelps KLH</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Meng+J%22">Meng J</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Soong+D%22">Soong D</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; Zebrafish Imaging and Screening Facility, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Scalia+E%22">Scalia E</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Lathem+K%22">Lathem K</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Keatinge+M%22">Keatinge M</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Richmond+C%22">Richmond C</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Klingseisen+A%22">Klingseisen A</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Main+M%22">Main M</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Neely+SA%22">Neely SA</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hampton+DW%22">Hampton DW</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Duncan+GJ%22">Duncan GJ</searchLink>; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Schenk+GJ%22">Schenk GJ</searchLink>; Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.; MS Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Groot+ML%22">Groot ML</searchLink>; Faculty of Science, Department of Physics, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Chandran+S%22">Chandran S</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute at University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Emery+B%22">Emery B</searchLink>; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Luchicchi+A%22">Luchicchi A</searchLink>; Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands.; MS Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kole+MHP%22">Kole MHP</searchLink>; Department of Axonal Signalling, Netherlands Institute for Neurosciences (NIN), Royal Netherlands Academy for Arts and Sciences (KNAW), Amsterdam, Netherlands.; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Williams+AC%22">Williams AC</searchLink>; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; Centre for Regenerative Medicine, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Lyons+DA%22">Lyons DA</searchLink>; Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.; MS Society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh, UK.; Zebrafish Imaging and Screening Facility, University of Edinburgh, Edinburgh, UK.; Euan MacDonald Centre for Motor Neuron Disease Research, Edinburgh, UK.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Feb 12; Vol. 391 (6786), pp. eadr4661. <i>Date of Electronic Publication: </i>2026 Feb 12.
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