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Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation.

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Title: Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation.
Authors: El-Brolosy MA; Harvard Society of Fellows, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Oak A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Hoang AT; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Damergi Y; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Fischer A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Saunders RA; Harvard Society of Fellows, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Luo J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Balabaki A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Guez J; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Whitfield TW; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Goldman SR; Nascent Transcriptomics Core, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Latifkar A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Lu YR; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Stainier DYR; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany., Karczewski KJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Corradin O; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Weissman JS; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Feb 12; Vol. 391 (6786), pp. eaea1272. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation.
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  Data: <searchLink fieldCode="AU" term="%22El-Brolosy+MA%22">El-Brolosy MA</searchLink>; Harvard Society of Fellows, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oak+A%22">Oak A</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+AT%22">Hoang AT</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Damergi+Y%22">Damergi Y</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+A%22">Fischer A</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saunders+RA%22">Saunders RA</searchLink>; Harvard Society of Fellows, Cambridge, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Balabaki+A%22">Balabaki A</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Guez+J%22">Guez J</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Whitfield+TW%22">Whitfield TW</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goldman+SR%22">Goldman SR</searchLink>; Nascent Transcriptomics Core, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Latifkar+A%22">Latifkar A</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+YR%22">Lu YR</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stainier+DYR%22">Stainier DYR</searchLink>; Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.<br /><searchLink fieldCode="AU" term="%22Karczewski+KJ%22">Karczewski KJ</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Corradin+O%22">Corradin O</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weissman+JS%22">Weissman JS</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Feb 12; Vol. 391 (6786), pp. eaea1272. <i>Date of Electronic Publication: </i>2026 Feb 12.
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