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Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance.

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Title: Disulfiram metabolite Cu(DDC)2 enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance.
Authors: Brookes K; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Fear JS; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Thornton CEM; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Zha L; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Kim J; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Small B; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK; Disulfican Ltd, University of Wolverhampton Science Park, Wolverhampton, UK., Wongsanit S; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Nieto HR; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Adcock H; School of Chemistry, University of Birmingham, Birmingham, UK., Jones A; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Pham TT; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Bottegoni G; Institute of Clinical Sciences, University of Birmingham, Birmingham, UK; Università degli Studi di Urbino Carlo Bo, Urbino, Italy., Cox LR; School of Chemistry, University of Birmingham, Birmingham, UK., Kannappan V; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK; Disulfican Ltd, University of Wolverhampton Science Park, Wolverhampton, UK., Wang W; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK; Disulfican Ltd, University of Wolverhampton Science Park, Wolverhampton, UK., Gorvin CM; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Stover DG; Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA., Spitzweg C; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany; Division Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA., Jhiang S; Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA., Ringel MD; Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA., Campbell MJ; Division of Cancer Biology, Cedars Sinai Cancer, Los Angeles, USA., Sunassee K; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Blower PJ; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Boelaert K; Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK., Smith VE; Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK., Read ML; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address: m.l.read.20@bham.ac.uk., McCabe CJ; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address: mccabcjz@bham.ac.uk.
Source: EBioMedicine [EBioMedicine] 2026 Mar; Vol. 125, pp. 106165. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Disulfiram metabolite Cu(DDC)<subscript>2</subscript> enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance.
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  Data: <searchLink fieldCode="AU" term="%22Brookes+K%22">Brookes K</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Fear+JS%22">Fear JS</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Thornton+CEM%22">Thornton CEM</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Zha+L%22">Zha L</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Small+B%22">Small B</searchLink>; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK; Disulfican Ltd, University of Wolverhampton Science Park, Wolverhampton, UK.<br /><searchLink fieldCode="AU" term="%22Wongsanit+S%22">Wongsanit S</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Nieto+HR%22">Nieto HR</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Adcock+H%22">Adcock H</searchLink>; School of Chemistry, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Jones+A%22">Jones A</searchLink>; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Pham+TT%22">Pham TT</searchLink>; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bottegoni+G%22">Bottegoni G</searchLink>; Institute of Clinical Sciences, University of Birmingham, Birmingham, UK; Università degli Studi di Urbino Carlo Bo, Urbino, Italy.<br /><searchLink fieldCode="AU" term="%22Cox+LR%22">Cox LR</searchLink>; School of Chemistry, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Kannappan+V%22">Kannappan V</searchLink>; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK; Disulfican Ltd, University of Wolverhampton Science Park, Wolverhampton, UK.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Research Institute in Healthcare Science, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK; Disulfican Ltd, University of Wolverhampton Science Park, Wolverhampton, UK.<br /><searchLink fieldCode="AU" term="%22Gorvin+CM%22">Gorvin CM</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Stover+DG%22">Stover DG</searchLink>; Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Spitzweg+C%22">Spitzweg C</searchLink>; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany; Division Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Jhiang+S%22">Jhiang S</searchLink>; Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Ringel+MD%22">Ringel MD</searchLink>; Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, The Ohio State University College of Medicine and Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+MJ%22">Campbell MJ</searchLink>; Division of Cancer Biology, Cedars Sinai Cancer, Los Angeles, USA.<br /><searchLink fieldCode="AU" term="%22Sunassee+K%22">Sunassee K</searchLink>; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Blower+PJ%22">Blower PJ</searchLink>; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Boelaert+K%22">Boelaert K</searchLink>; Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Smith+VE%22">Smith VE</searchLink>; Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Read+ML%22">Read ML</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address: m.l.read.20@bham.ac.uk.<br /><searchLink fieldCode="AU" term="%22McCabe+CJ%22">McCabe CJ</searchLink>; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK. Electronic address: mccabcjz@bham.ac.uk.
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