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Modulation of HMGB1-mediated neuroinflammation and synaptic plasticity by ethyl pyruvate reduces methamphetamine reward and motivation in male rats.

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Title: Modulation of HMGB1-mediated neuroinflammation and synaptic plasticity by ethyl pyruvate reduces methamphetamine reward and motivation in male rats.
Authors: Liu H; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China., Wang F; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China., Zhang Z; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China., Huang X; Department of Obstetrics, The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315040, China., Chen S; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China., Wang Y; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China., Zhou Y; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China., Wu T; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China., Wu M; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Shi B; School of Psychology and Mental Health, North China University of Science and Technology, Tang'shan 063210, Hebei Province, China., Lai M; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China., Liu H; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China., Zhou W; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China. Electronic address: whzhou@vip.163.com.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 May; Vol. 134, pp. 106481. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Modulation of HMGB1-mediated neuroinflammation and synaptic plasticity by ethyl pyruvate reduces methamphetamine reward and motivation in male rats.
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  Data: <searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Obstetrics, The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315040, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wu+T%22">Wu T</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+B%22">Shi B</searchLink>; School of Psychology and Mental Health, North China University of Science and Technology, Tang'shan 063210, Hebei Province, China.<br /><searchLink fieldCode="AU" term="%22Lai+M%22">Lai M</searchLink>; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo 315201, Zhejiang, China. Electronic address: whzhou@vip.163.com.
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  Data: <searchLink fieldCode="JN" term="%228800478%22">Brain, behavior, and immunity</searchLink> [Brain Behav Immun] 2026 May; Vol. 134, pp. 106481. <i>Date of Electronic Publication: </i>2026 Feb 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8800478 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2139 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208891591%22">08891591 </searchLink><i>NLM ISO Abbreviation: </i>Brain Behav Immun <i>Subsets: </i>MEDLINE
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              Text: 2026 May
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