Design and rationale of a multicenter paramedic randomized trial of noradrenaline versus adrenaline in the initial management of patients with cardiogenic shock-The PANDA trial.
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| Title: | Design and rationale of a multicenter paramedic randomized trial of noradrenaline versus adrenaline in the initial management of patients with cardiogenic shock-The PANDA trial. |
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| Authors: | Bloom JE; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Ball J; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Okyere D; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Voskoboinik A; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University., Dawson LP; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Nelson AJ; Royal Adelaide Hospital, Adelaide, South Australia, Australia., Percival M; Ambulance Victoria, Blackburn, Victoria, Australia., Meadley B; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Salathiel R; Ambulance Victoria, Blackburn, Victoria, Australia., McManamny T; Ambulance Victoria, Blackburn, Victoria, Australia; Department of Paramedicine, Monash University, Frankston, Victoria, Australia., Boggett S; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Batchelor R; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Hartshorne T; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University., Palmer S; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University., Reid C; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Curtin University, Bentley, Western Australia, Australia., Anderson D; Alfred Health, Melbourne, Victoria, Australia; Ambulance Victoria, Blackburn, Victoria, Australia., Pilcher D; Alfred Health, Melbourne, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Chew DP; Victorian Heart Hospital, Clayton, Victoria, Australia., Kaye DM; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University., Nehme Z; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Stub D; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address: d.stub@alfred.org.au. |
| Corporate Authors: | PANDA Investigators |
| Source: | American heart journal [Am Heart J] 2026 Jul; Vol. 297, pp. 107378. Date of Electronic Publication: 2026 Feb 10. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41679570 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Design and rationale of a multicenter paramedic randomized trial of noradrenaline versus adrenaline in the initial management of patients with cardiogenic shock-The PANDA trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bloom+JE%22">Bloom JE</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ball+J%22">Ball J</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Okyere+D%22">Okyere D</searchLink>; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Voskoboinik+A%22">Voskoboinik A</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University.<br /><searchLink fieldCode="AU" term="%22Dawson+LP%22">Dawson LP</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Nelson+AJ%22">Nelson AJ</searchLink>; Royal Adelaide Hospital, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Percival+M%22">Percival M</searchLink>; Ambulance Victoria, Blackburn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Meadley+B%22">Meadley B</searchLink>; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Salathiel+R%22">Salathiel R</searchLink>; Ambulance Victoria, Blackburn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22McManamny+T%22">McManamny T</searchLink>; Ambulance Victoria, Blackburn, Victoria, Australia; Department of Paramedicine, Monash University, Frankston, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Boggett+S%22">Boggett S</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Batchelor+R%22">Batchelor R</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hartshorne+T%22">Hartshorne T</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University.<br /><searchLink fieldCode="AU" term="%22Palmer+S%22">Palmer S</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University.<br /><searchLink fieldCode="AU" term="%22Reid+C%22">Reid C</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Curtin University, Bentley, Western Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Anderson+D%22">Anderson D</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Ambulance Victoria, Blackburn, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Pilcher+D%22">Pilcher D</searchLink>; Alfred Health, Melbourne, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chew+DP%22">Chew DP</searchLink>; Victorian Heart Hospital, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kaye+DM%22">Kaye DM</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University.<br /><searchLink fieldCode="AU" term="%22Nehme+Z%22">Nehme Z</searchLink>; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Stub+D%22">Stub D</searchLink>; Alfred Health, Melbourne, Victoria, Australia; Monash Alfred Baker Centre for Cardiovascular Research, Monash University; Ambulance Victoria, Blackburn, Victoria, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address: d.stub@alfred.org.au. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22PANDA+Investigators%22">PANDA Investigators</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220370465%22">American heart journal</searchLink> [Am Heart J] 2026 Jul; Vol. 297, pp. 107378. <i>Date of Electronic Publication: </i>2026 Feb 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370465 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6744 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200028703%22">00028703 </searchLink><i>NLM ISO Abbreviation: </i>Am Heart J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41679570 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ahj.2026.107378 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107378 Titles: – TitleFull: Design and rationale of a multicenter paramedic randomized trial of noradrenaline versus adrenaline in the initial management of patients with cardiogenic shock-The PANDA trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bloom JE – PersonEntity: Name: NameFull: Ball J – PersonEntity: Name: NameFull: Okyere D – PersonEntity: Name: NameFull: Voskoboinik A – PersonEntity: Name: NameFull: Dawson LP – PersonEntity: Name: NameFull: Nelson AJ – PersonEntity: Name: NameFull: Percival M – PersonEntity: Name: NameFull: Meadley B – PersonEntity: Name: NameFull: Salathiel R – PersonEntity: Name: NameFull: McManamny T – PersonEntity: Name: NameFull: Boggett S – PersonEntity: Name: NameFull: Batchelor R – PersonEntity: Name: NameFull: Hartshorne T – PersonEntity: Name: NameFull: Palmer S – PersonEntity: Name: NameFull: Reid C – PersonEntity: Name: NameFull: Anderson D – PersonEntity: Name: NameFull: Pilcher D – PersonEntity: Name: NameFull: Chew DP – PersonEntity: Name: NameFull: Kaye DM – PersonEntity: Name: NameFull: Nehme Z – PersonEntity: Name: NameFull: Stub D IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2026 Jul Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1097-6744 Numbering: – Type: volume Value: 297 Titles: – TitleFull: American heart journal Type: main |
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