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Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.

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Title: Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.
Authors: Chang RC; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Egusquiza RJ; Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA., Amato AA; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of Brasília, Brasília, Brazil., Li Z; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Dougherty AL; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., To KT; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Avila M; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Joloya EM; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Wheeler HB; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Nguyen A; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Shioda K; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA., Odajima J; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA., Lawrence MS; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA., Shioda T; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA. shioda@mgh.harvard.edu., Blumberg B; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA. blumberg@uci.edu.
Source: Nature communications [Nat Commun] 2026 Feb 12; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet-induced insulin dysregulation and obesity.
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  Data: <searchLink fieldCode="AU" term="%22Chang+RC%22">Chang RC</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Egusquiza+RJ%22">Egusquiza RJ</searchLink>; Department of Pharmaceutical Sciences, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Amato+AA%22">Amato AA</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.; Department of Pharmaceutical Sciences, University of Brasília, Brasília, Brazil.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dougherty+AL%22">Dougherty AL</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22To+KT%22">To KT</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Avila+M%22">Avila M</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Joloya+EM%22">Joloya EM</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wheeler+HB%22">Wheeler HB</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+A%22">Nguyen A</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shioda+K%22">Shioda K</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Odajima+J%22">Odajima J</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+MS%22">Lawrence MS</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shioda+T%22">Shioda T</searchLink>; Krantz Family Center for Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA. shioda@mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Blumberg+B%22">Blumberg B</searchLink>; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA. blumberg@uci.edu.
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