Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries Syndrome.

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Title: Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries Syndrome.
Authors: Verboven AHA; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Puvogel S; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Latour BL; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Kolsters N; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Lewerissa EI; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Mijdam R; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Dyke E; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Duineveld D; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Zoodsma M; Department of Medical BioSciences, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands., Claassen WJJ; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Oudakker A; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Schoenmaker C; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., Koolen DA; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., de Vries BBA; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands., 't Hoen PAC; Department of Medical BioSciences, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands., Linda K; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands. Katrin.Linda1@radboudumc.nl., Nadif Kasri N; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition, and Behaviour, 6500 HB, Nijmegen, the Netherlands. nael.nadifkasri@radboudumc.nl.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun; Vol. 31 (6), pp. 3558-3575. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-026-03482-x