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Interpreting cancer genetics through a two-step "evolutionary cascade hypothesis": bridging neutral and selective perspectives.

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Title: Interpreting cancer genetics through a two-step "evolutionary cascade hypothesis": bridging neutral and selective perspectives.
Authors: Ottaiano A; Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131, Naples, Italy. a.ottaiano@istitutotumori.na.it., Santorsola M; Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131, Naples, Italy., Sabbatino F; Medical Oncology, University of Salerno, Via Salvador Allende 43, 84081, Baronissi, Italy., Sirica R; Centro Polidiagnostico Strumentale srl, AMES, Via Padre Carmine Fico 24, 80013, Casalnuovo Di Napoli, Italy., Caraglia F; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138, Naples, Italy., Ceccarelli A; Medical Oncology, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy., Granata V; Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131, Naples, Italy., Simeone I; University of Naples 'Federico II', Via Sergio Pansini 5, 80131, Naples, Italy., Zappavigna S; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138, Naples, Italy., Berretta M; Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy., Savarese G; Centro Polidiagnostico Strumentale srl, AMES, Via Padre Carmine Fico 24, 80013, Casalnuovo Di Napoli, Italy., Caraglia M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138, Naples, Italy. michele.caraglia@unicampania.it.; Laboratory of Molecular and Precision Oncology, Biogem SCARL, Ariano Irpino (AV), Italy. michele.caraglia@unicampania.it.
Source: Journal of translational medicine [J Transl Med] 2026 Feb 13; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interpreting cancer genetics through a two-step "evolutionary cascade hypothesis": bridging neutral and selective perspectives.
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  Data: <searchLink fieldCode="AU" term="%22Ottaiano+A%22">Ottaiano A</searchLink>; Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131, Naples, Italy. a.ottaiano@istitutotumori.na.it.<br /><searchLink fieldCode="AU" term="%22Santorsola+M%22">Santorsola M</searchLink>; Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Sabbatino+F%22">Sabbatino F</searchLink>; Medical Oncology, University of Salerno, Via Salvador Allende 43, 84081, Baronissi, Italy.<br /><searchLink fieldCode="AU" term="%22Sirica+R%22">Sirica R</searchLink>; Centro Polidiagnostico Strumentale srl, AMES, Via Padre Carmine Fico 24, 80013, Casalnuovo Di Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Caraglia+F%22">Caraglia F</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ceccarelli+A%22">Ceccarelli A</searchLink>; Medical Oncology, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Granata+V%22">Granata V</searchLink>; Istituto Nazionale Tumori di Napoli, IRCCS 'G. Pascale', Via M. Semmola, 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Simeone+I%22">Simeone I</searchLink>; University of Naples 'Federico II', Via Sergio Pansini 5, 80131, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Zappavigna+S%22">Zappavigna S</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Berretta+M%22">Berretta M</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Savarese+G%22">Savarese G</searchLink>; Centro Polidiagnostico Strumentale srl, AMES, Via Padre Carmine Fico 24, 80013, Casalnuovo Di Napoli, Italy.<br /><searchLink fieldCode="AU" term="%22Caraglia+M%22">Caraglia M</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Via Luigi De Crecchio 7, 80138, Naples, Italy. michele.caraglia@unicampania.it.; Laboratory of Molecular and Precision Oncology, Biogem SCARL, Ariano Irpino (AV), Italy. michele.caraglia@unicampania.it.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Feb 13; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 13
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