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The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes.

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Title: The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes.
Authors: Almeida LM; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal., Lima LP; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal., Oliveira NAS; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal., Silva RFO; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal., Sousa B; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal., Bessa J; Instituto de Biologia Molecular e Celular, IBMC, Universidade do Porto, Porto, 4200-135, Portugal.; i3S Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal., Pinho BR; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal., Oliveira JMA; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal. jorgemao@ff.up.pt.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal. jorgemao@ff.up.pt.; Departamento de Ciências do Medicamento, Laboratório de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal. jorgemao@ff.up.pt.
Source: Pharmacological reports : PR [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 487-504. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22Almeida+LM%22">Almeida LM</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal.<br /><searchLink fieldCode="AU" term="%22Lima+LP%22">Lima LP</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal.<br /><searchLink fieldCode="AU" term="%22Oliveira+NAS%22">Oliveira NAS</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal.<br /><searchLink fieldCode="AU" term="%22Silva+RFO%22">Silva RFO</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal.<br /><searchLink fieldCode="AU" term="%22Sousa+B%22">Sousa B</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal.<br /><searchLink fieldCode="AU" term="%22Bessa+J%22">Bessa J</searchLink>; Instituto de Biologia Molecular e Celular, IBMC, Universidade do Porto, Porto, 4200-135, Portugal.; i3S Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, 4200-135, Portugal.<br /><searchLink fieldCode="AU" term="%22Pinho+BR%22">Pinho BR</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal.<br /><searchLink fieldCode="AU" term="%22Oliveira+JMA%22">Oliveira JMA</searchLink>; Applied Molecular Biosciences Unit, Mitochondria and Neurobiology Lab, Faculdade de Farmácia, UCIBIO, Universidade do Porto, Porto, 4050-313, Portugal. jorgemao@ff.up.pt.; i4HB, Institute for Health and Bioeconomy, Universidade do Porto, Porto, 4050-313, Portugal. jorgemao@ff.up.pt.; Departamento de Ciências do Medicamento, Laboratório de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal. jorgemao@ff.up.pt.
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  Data: <searchLink fieldCode="JN" term="%22101234999%22">Pharmacological reports : PR</searchLink> [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 487-504. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101234999 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2299-5684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217341140%22">17341140 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Rep <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s43440-026-00837-7
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        Text: English
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            NameFull: Almeida LM
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              Text: 2026 Apr
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              Y: 2026
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