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Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice.

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Title: Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice.
Authors: Dipol T; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy., Morsilli O; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Fortuna A; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Zecca V; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.; Department of Basic and Applied Sciences for Engineering, University of Rome Sapienza, Rome, Italy., Palombelli G; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Maroccia Z; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Belfiore M; National Centre for Preclinical and Clinical Evaluation and Research of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Campana G; Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy., Ricceri L; Centre for Behavioural Sciences and Mental Health, Istituto Superiore Di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Feligioni M; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini, Viale Regina Elena 295, 00161, Rome, Italy.; Department of Neurorehabilitation Sciences, Casa di Cura IGEA, 20144, Milan, Italy., Motta C; Memory Clinic and Neurodegenerative Dementia Research Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy., Martorana A; Memory Clinic and Neurodegenerative Dementia Research Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy., Koch G; Non Invasive Brain Stimulation Unit, IRCCS Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy.; Center for Translational Neurophysiology, Istituto Italiano di Tecnologia, Via Fossato di Mortara 19, 44121, Ferrara, Italy.; Section of Physiology, Department of Neuroscience and Rehabilitation, University of Ferrara, via Ludovico Ariosto 35, 44121, Ferrara, Italy., Onder G; Fondazione Policlinico Gemelli IRCCS, Largo Agostino Gemelli 8, 00136, Rome, Italy.; Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy., Pierri CL; Department of Pharmacy, Pharmaceutical Sciences, University of Bari 'Aldo Moro', Via Orabona 4, 70125, Bari, Italy., Canese R; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Loizzo S; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. stefano.loizzo@iss.it.
Source: Pharmacological reports : PR [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 446-465. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice.
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  Data: <searchLink fieldCode="AU" term="%22Dipol+T%22">Dipol T</searchLink>; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Morsilli+O%22">Morsilli O</searchLink>; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fortuna+A%22">Fortuna A</searchLink>; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zecca+V%22">Zecca V</searchLink>; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.; Department of Basic and Applied Sciences for Engineering, University of Rome Sapienza, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Palombelli+G%22">Palombelli G</searchLink>; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Maroccia+Z%22">Maroccia Z</searchLink>; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Belfiore+M%22">Belfiore M</searchLink>; National Centre for Preclinical and Clinical Evaluation and Research of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Campana+G%22">Campana G</searchLink>; Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Ricceri+L%22">Ricceri L</searchLink>; Centre for Behavioural Sciences and Mental Health, Istituto Superiore Di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Feligioni+M%22">Feligioni M</searchLink>; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini, Viale Regina Elena 295, 00161, Rome, Italy.; Department of Neurorehabilitation Sciences, Casa di Cura IGEA, 20144, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Motta+C%22">Motta C</searchLink>; Memory Clinic and Neurodegenerative Dementia Research Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Martorana+A%22">Martorana A</searchLink>; Memory Clinic and Neurodegenerative Dementia Research Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Koch+G%22">Koch G</searchLink>; Non Invasive Brain Stimulation Unit, IRCCS Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy.; Center for Translational Neurophysiology, Istituto Italiano di Tecnologia, Via Fossato di Mortara 19, 44121, Ferrara, Italy.; Section of Physiology, Department of Neuroscience and Rehabilitation, University of Ferrara, via Ludovico Ariosto 35, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Onder+G%22">Onder G</searchLink>; Fondazione Policlinico Gemelli IRCCS, Largo Agostino Gemelli 8, 00136, Rome, Italy.; Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pierri+CL%22">Pierri CL</searchLink>; Department of Pharmacy, Pharmaceutical Sciences, University of Bari 'Aldo Moro', Via Orabona 4, 70125, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Canese+R%22">Canese R</searchLink>; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Loizzo+S%22">Loizzo S</searchLink>; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. stefano.loizzo@iss.it.
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  Data: <searchLink fieldCode="JN" term="%22101234999%22">Pharmacological reports : PR</searchLink> [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 446-465. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101234999 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2299-5684 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217341140%22">17341140 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Rep <i>Subsets: </i>MEDLINE
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