Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice.
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| Title: | Chronic fasudil treatment induces benzodiazepine-like tolerance via modulation of GABA-A receptor γ2 subunit expression and impairs contextual fear memory in mice. |
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| Authors: | Dipol T; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy., Morsilli O; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Fortuna A; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Zecca V; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.; Department of Basic and Applied Sciences for Engineering, University of Rome Sapienza, Rome, Italy., Palombelli G; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Maroccia Z; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Belfiore M; National Centre for Preclinical and Clinical Evaluation and Research of Drugs, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Campana G; Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy., Ricceri L; Centre for Behavioural Sciences and Mental Health, Istituto Superiore Di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Feligioni M; Fondazione European Brain Research Institute (EBRI) Rita Levi-Montalcini, Viale Regina Elena 295, 00161, Rome, Italy.; Department of Neurorehabilitation Sciences, Casa di Cura IGEA, 20144, Milan, Italy., Motta C; Memory Clinic and Neurodegenerative Dementia Research Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy., Martorana A; Memory Clinic and Neurodegenerative Dementia Research Unit, University of Rome Tor Vergata, Viale Oxford 81, 00133, Rome, Italy., Koch G; Non Invasive Brain Stimulation Unit, IRCCS Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy.; Center for Translational Neurophysiology, Istituto Italiano di Tecnologia, Via Fossato di Mortara 19, 44121, Ferrara, Italy.; Section of Physiology, Department of Neuroscience and Rehabilitation, University of Ferrara, via Ludovico Ariosto 35, 44121, Ferrara, Italy., Onder G; Fondazione Policlinico Gemelli IRCCS, Largo Agostino Gemelli 8, 00136, Rome, Italy.; Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy., Pierri CL; Department of Pharmacy, Pharmaceutical Sciences, University of Bari 'Aldo Moro', Via Orabona 4, 70125, Bari, Italy., Canese R; Core Facilities, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy., Loizzo S; Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. stefano.loizzo@iss.it. |
| Source: | Pharmacological reports : PR [Pharmacol Rep] 2026 Apr; Vol. 78 (2), pp. 446-465. Date of Electronic Publication: 2026 Feb 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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