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Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation.

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Title: Munc13-1 couples DAG and Ca2+ signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation.
Authors: Ranjan M; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Göttingen, Germany., Lin KH; Laboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Mueller BD; Howard Hughes Medical Institute (HHMI), School of Biological Sciences, University of Utah, Salt Lake City, UT, USA., Wojcik SM; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Lohse M; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Göttingen, Germany.; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Südhof TC; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA, USA., Jorgensen EM; Howard Hughes Medical Institute (HHMI), School of Biological Sciences, University of Utah, Salt Lake City, UT, USA., Neher E; Laboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Macau University of Science and Technology, Macau.; Shenzhen Institute of Advanced Technology, Shenzhen, China., Lipstein N; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Brose N; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Taschenberger H; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Source: Science advances [Sci Adv] 2026 Feb 13; Vol. 12 (7), pp. eaea0449. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Munc13-1 couples DAG and Ca<superscript>2+</superscript> signaling to dynamic vesicle priming, synaptic short-term plasticity, and posttetanic potentiation.
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  Data: <searchLink fieldCode="AU" term="%22Ranjan+M%22">Ranjan M</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Lin+KH%22">Lin KH</searchLink>; Laboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+BD%22">Mueller BD</searchLink>; Howard Hughes Medical Institute (HHMI), School of Biological Sciences, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Wojcik+SM%22">Wojcik SM</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Lohse+M%22">Lohse M</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, Göttingen, Germany.; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Südhof+TC%22">Südhof TC</searchLink>; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute (HHMI), Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jorgensen+EM%22">Jorgensen EM</searchLink>; Howard Hughes Medical Institute (HHMI), School of Biological Sciences, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Neher+E%22">Neher E</searchLink>; Laboratory of Membrane Biophysics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Macau University of Science and Technology, Macau.; Shenzhen Institute of Advanced Technology, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Lipstein+N%22">Lipstein N</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Brose+N%22">Brose N</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Taschenberger+H%22">Taschenberger H</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Feb 13; Vol. 12 (7), pp. eaea0449. <i>Date of Electronic Publication: </i>2026 Feb 13.
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