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Myxarylin: Total In Vitro Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides.

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Title: Myxarylin: Total In Vitro Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides.
Authors: Sikandar A; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0QX, U.K., Vianey L; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany., Schließmann K; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany., Shen Q; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany., Mackay CL; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0QX, U.K., Haeckl FPJ; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany., Urlacher VB; Institute of Biochemistry, Heinrich-Heine University Düsseldorf, Düsseldorf 40225, Germany., Naismith JH; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0QX, U.K.; University of Oxford, Division of Structural Biology, Oxford OX3 7BN, U.K., Müller R; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.; Department of Pharmacy, Pharmaceutical Biotechnology, Saarland University, Saarbrücken 66123, Germany.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Feb 25; Vol. 148 (7), pp. 6970-6980. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE; In Process
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  Data: <searchLink fieldCode="AU" term="%22Sikandar+A%22">Sikandar A</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0QX, U.K.<br /><searchLink fieldCode="AU" term="%22Vianey+L%22">Vianey L</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.<br /><searchLink fieldCode="AU" term="%22Schließmann+K%22">Schließmann K</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.<br /><searchLink fieldCode="AU" term="%22Shen+Q%22">Shen Q</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.<br /><searchLink fieldCode="AU" term="%22Mackay+CL%22">Mackay CL</searchLink>; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0QX, U.K.<br /><searchLink fieldCode="AU" term="%22Haeckl+FPJ%22">Haeckl FPJ</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.<br /><searchLink fieldCode="AU" term="%22Urlacher+VB%22">Urlacher VB</searchLink>; Institute of Biochemistry, Heinrich-Heine University Düsseldorf, Düsseldorf 40225, Germany.<br /><searchLink fieldCode="AU" term="%22Naismith+JH%22">Naismith JH</searchLink>; The Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0QX, U.K.; University of Oxford, Division of Structural Biology, Oxford OX3 7BN, U.K.<br /><searchLink fieldCode="AU" term="%22Müller+R%22">Müller R</searchLink>; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Saarbrücken, 66123, Germany.; Department of Pharmacy, Pharmaceutical Biotechnology, Saarland University, Saarbrücken 66123, Germany.
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  Data: <searchLink fieldCode="JN" term="%227503056%22">Journal of the American Chemical Society</searchLink> [J Am Chem Soc] 2026 Feb 25; Vol. 148 (7), pp. 6970-6980. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7503056 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-5126 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200027863%22">00027863 </searchLink><i>NLM ISO Abbreviation: </i>J Am Chem Soc <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1021/jacs.5c17257
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              Text: 2026 Feb 25
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