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A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells.

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Title: A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells.
Authors: Brescia M; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands., Gallant J; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands., Chatrian A; Sartorius Stedim Data Analytics Ab, Corporate Research, Umeå, Sweden., Keselman P; Sartorius Stedim North America Inc., Corporate Research, Bohemia, NY, USA., Paulsson ES; Sartorius Stedim Data Analytics Ab, Corporate Research, Umeå, Sweden., Mol MPH; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands., Sjögren R; Sartorius Stedim Data Analytics Ab, Corporate Research, Umeå, Sweden., Raymond K; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands; University of Grenoble Alpes, CEA, INSERM, IRIG, UA13 BGE, Biomics, Grenoble, France., Orlova V; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands., Barnes K; Essen Bioscience Ltd., Product Development, Royston, UK., Wales R; The Automation Partnership (Cambridge) Ltd., Corporate Research, Royston, UK., Austerjost J; Sartorius Stedim Biotech GmbH, Corporate Research, Göttingen, Germany., Olszowy MW; Sartorius Stedim North America Inc., Corporate Research, Bohemia, NY, USA., Mummery CL; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands., van Meer BJ; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: berend.van.meer@demcon.com., Davis RP; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.p.davis@lumc.nl.
Source: Stem cell reports [Stem Cell Reports] 2026 Mar 10; Vol. 21 (3), pp. 102816. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells.
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  Data: <searchLink fieldCode="AU" term="%22Brescia+M%22">Brescia M</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gallant+J%22">Gallant J</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Chatrian+A%22">Chatrian A</searchLink>; Sartorius Stedim Data Analytics Ab, Corporate Research, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Keselman+P%22">Keselman P</searchLink>; Sartorius Stedim North America Inc., Corporate Research, Bohemia, NY, USA.<br /><searchLink fieldCode="AU" term="%22Paulsson+ES%22">Paulsson ES</searchLink>; Sartorius Stedim Data Analytics Ab, Corporate Research, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Mol+MPH%22">Mol MPH</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sjögren+R%22">Sjögren R</searchLink>; Sartorius Stedim Data Analytics Ab, Corporate Research, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Raymond+K%22">Raymond K</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands; University of Grenoble Alpes, CEA, INSERM, IRIG, UA13 BGE, Biomics, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Orlova+V%22">Orlova V</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Barnes+K%22">Barnes K</searchLink>; Essen Bioscience Ltd., Product Development, Royston, UK.<br /><searchLink fieldCode="AU" term="%22Wales+R%22">Wales R</searchLink>; The Automation Partnership (Cambridge) Ltd., Corporate Research, Royston, UK.<br /><searchLink fieldCode="AU" term="%22Austerjost+J%22">Austerjost J</searchLink>; Sartorius Stedim Biotech GmbH, Corporate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Olszowy+MW%22">Olszowy MW</searchLink>; Sartorius Stedim North America Inc., Corporate Research, Bohemia, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mummery+CL%22">Mummery CL</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Meer+BJ%22">van Meer BJ</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: berend.van.meer@demcon.com.<br /><searchLink fieldCode="AU" term="%22Davis+RP%22">Davis RP</searchLink>; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; The Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.p.davis@lumc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101611300%22">Stem cell reports</searchLink> [Stem Cell Reports] 2026 Mar 10; Vol. 21 (3), pp. 102816. <i>Date of Electronic Publication: </i>2026 Feb 12.
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