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LDN-57444 sensitizes hepatocellular carcinoma cells to sorafenib by promoting ferroptosis through histone deacetylase 2 (HDAC2) inhibition.

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Title: LDN-57444 sensitizes hepatocellular carcinoma cells to sorafenib by promoting ferroptosis through histone deacetylase 2 (HDAC2) inhibition.
Authors: Lin JC; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, 112021, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan., Huang TS; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan., Chen YB; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan., Chen TY; Department of Pathology, MacKay Memorial Hospital, Taipei, 104217, Taiwan., Wu PS; Department of Anatomical Pathology, Far Eastern Memorial Hospital, New Taipei City, 220216, Taiwan., Liu TP; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, 112021, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan., Yang PM; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan. yangpm@tmu.edu.tw.; Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; TMU Research Center of Cancer Translational Medicine, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, 116079, Taiwan. yangpm@tmu.edu.tw.; TMU and Affiliated Hospitals Pancreatic Cancer Groups, Taipei Medical University, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, 301 Yuantong Rd., Zhonghe Dist, New Taipei City, 235603, Taiwan. yangpm@tmu.edu.tw.
Source: Biology direct [Biol Direct] 2026 Feb 13; Vol. 21 (1). Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101258412 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6150 (Electronic) Linking ISSN: 17456150 NLM ISO Abbreviation: Biol Direct Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: LDN-57444 sensitizes hepatocellular carcinoma cells to sorafenib by promoting ferroptosis through histone deacetylase 2 (HDAC2) inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Lin+JC%22">Lin JC</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, 112021, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+TS%22">Huang TS</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YB%22">Chen YB</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TY%22">Chen TY</searchLink>; Department of Pathology, MacKay Memorial Hospital, Taipei, 104217, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+PS%22">Wu PS</searchLink>; Department of Anatomical Pathology, Far Eastern Memorial Hospital, New Taipei City, 220216, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+TP%22">Liu TP</searchLink>; Department of Surgery, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; MacKay Junior College of Medicine, Nursing and Management, New Taipei City, 112021, Taiwan.; Department of Medicine, MacKay Medical University, New Taipei City, 252005, Taiwan.; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan.; Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+PM%22">Yang PM</searchLink>; Liver Medical Center, MacKay Memorial Hospital, Taipei, 104217, Taiwan. yangpm@tmu.edu.tw.; Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; TMU Research Center of Cancer Translational Medicine, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, 116079, Taiwan. yangpm@tmu.edu.tw.; TMU and Affiliated Hospitals Pancreatic Cancer Groups, Taipei Medical University, Taipei, 110301, Taiwan. yangpm@tmu.edu.tw.; Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, 301 Yuantong Rd., Zhonghe Dist, New Taipei City, 235603, Taiwan. yangpm@tmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101258412%22">Biology direct</searchLink> [Biol Direct] 2026 Feb 13; Vol. 21 (1). <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101258412 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6150 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456150%22">17456150 </searchLink><i>NLM ISO Abbreviation: </i>Biol Direct <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 13
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