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Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation.

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Title: Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation.
Authors: Liu JY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China. Electronic address: jiayuliu@fjmu.edu.cn., Chen J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China., Chen QY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China., Li HB; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China., Gui LX; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China., Zhou J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University, Beijing 100191, China. Electronic address: jzhou@bjmu.edu.cn., Lin MJ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China. Electronic address: mjlin@mail.fjmu.edu.cn.
Source: Cell reports [Cell Rep] 2026 Feb 24; Vol. 45 (2), pp. 116992. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liquid-liquid phase separation of EphB4 drives pulmonary hypertension via YAP activation.
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  Data: <searchLink fieldCode="AU" term="%22Liu+JY%22">Liu JY</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China. Electronic address: jiayuliu@fjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China.<br /><searchLink fieldCode="AU" term="%22Chen+QY%22">Chen QY</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China.<br /><searchLink fieldCode="AU" term="%22Li+HB%22">Li HB</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China.<br /><searchLink fieldCode="AU" term="%22Gui+LX%22">Gui LX</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University, Beijing 100191, China. Electronic address: jzhou@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lin+MJ%22">Lin MJ</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, Fujian Medical University, Fuzhou 350122, China. Electronic address: mjlin@mail.fjmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Feb 24; Vol. 45 (2), pp. 116992. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101573691 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2211-1247 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Rep <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 24
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