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The protective effect of febuxostat in a rotenone mouse model of Parkinson's disease: the interplay between PI3K/Akt/mTOR, GSK-3β, and Nrf2/HO-1 signaling pathways.

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Title: The protective effect of febuxostat in a rotenone mouse model of Parkinson's disease: the interplay between PI3K/Akt/mTOR, GSK-3β, and Nrf2/HO-1 signaling pathways.
Authors: Lasheen KM; School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt., Mohammad Z; School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt., Ahmed N; School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt., El-Sahar AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr Al-Ainy Street, El-Manial District, Cairo 11562, Egypt., Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr Al-Ainy Street, El-Manial District, Cairo 11562, Egypt.; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt.
Source: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2026 Feb 06; Vol. 78 (2).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lasheen+KM%22">Lasheen KM</searchLink>; School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohammad+Z%22">Mohammad Z</searchLink>; School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+N%22">Ahmed N</searchLink>; School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sahar+AE%22">El-Sahar AE</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr Al-Ainy Street, El-Manial District, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Sayed+RH%22">Sayed RH</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr Al-Ainy Street, El-Manial District, Cairo 11562, Egypt.; Clinical Pharmacy Department, School of Pharmacy, Newgiza University, Cairo-Alexandria Desert Road, First 6th of October City, Giza 12563, Egypt.
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  Data: <searchLink fieldCode="JN" term="%220376363%22">The Journal of pharmacy and pharmacology</searchLink> [J Pharm Pharmacol] 2026 Feb 06; Vol. 78 (2).
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        Value: 10.1093/jpp/rgag009
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        Text: English
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      – TitleFull: The protective effect of febuxostat in a rotenone mouse model of Parkinson's disease: the interplay between PI3K/Akt/mTOR, GSK-3β, and Nrf2/HO-1 signaling pathways.
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              Text: 2026 Feb 06
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