Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma.

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Title: Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma.
Authors: Xu C; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China. Electronic address: xucheng@sysucc.org.cn., Lin ZQ; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Wang YZ; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510000, P.R. China., Shen JX; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Li WF; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Zhou GQ; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Yang KB; Department of Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China., Wen MY; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Zhang YN; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China; Sun Yat-sen University School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong 510000, P.R. China., Shen LF; Department of Radiation Oncology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China., Yang KY; Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China., Chen XZ; Department of Head and Neck Tumor Radiotherapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, P.R. China., Hu DS; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China., Lin SJ; Department of Radiation Oncology, Cancer Hospital of Fujian Medical University (Fujian Provincial Cancer Hospital), Fuzhou, Fujian 350014, P.R. China., Jin F; Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550000, P.R. China., Li JB; Clinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China., Lin AH; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510000, P.R. China., Zhao HY; Department of Medical Oncology and Department of Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China., Hong SB; Department of Endocrinology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510000, P.R. China., Huang HL; Department of Cardiology, Cardiac Prevention and Assessment Center, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510000, P.R. China., Zhang Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Liu X; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Li YQ; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Tang LL; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China., Sun Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China; Chinese Society of Clinical Oncology, Beijing 100000, P.R. China., Ma J; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China; Chinese Society of Clinical Oncology, Beijing 100000, P.R. China; Department of Radiation Oncology, Cancer Treatment Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P. R. China. Electronic address: majun2@mail.sysu.edu.cn.
Source: Med (New York, N.Y.) [Med] 2026 Mar 13; Vol. 7 (3), pp. 100994. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769215 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-6340 (Electronic) Linking ISSN: 26666340 NLM ISO Abbreviation: Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Patient-reported outcomes from a phase 2 PLATINUM trial of nivolumab combination therapy sparing concurrent cisplatin in nasopharyngeal carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China. Electronic address: xucheng@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Lin+ZQ%22">Lin ZQ</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+YZ%22">Wang YZ</searchLink>; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Shen+JX%22">Shen JX</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+WF%22">Li WF</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhou+GQ%22">Zhou GQ</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yang+KB%22">Yang KB</searchLink>; Department of Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wen+MY%22">Wen MY</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+YN%22">Zhang YN</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China; Sun Yat-sen University School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Shen+LF%22">Shen LF</searchLink>; Department of Radiation Oncology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yang+KY%22">Yang KY</searchLink>; Department of Oncology, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+XZ%22">Chen XZ</searchLink>; Department of Head and Neck Tumor Radiotherapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang 310022, P.R. China.<br /><searchLink fieldCode="AU" term="%22Hu+DS%22">Hu DS</searchLink>; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lin+SJ%22">Lin SJ</searchLink>; Department of Radiation Oncology, Cancer Hospital of Fujian Medical University (Fujian Provincial Cancer Hospital), Fuzhou, Fujian 350014, P.R. China.<br /><searchLink fieldCode="AU" term="%22Jin+F%22">Jin F</searchLink>; Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+JB%22">Li JB</searchLink>; Clinical Trials Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lin+AH%22">Lin AH</searchLink>; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhao+HY%22">Zhao HY</searchLink>; Department of Medical Oncology and Department of Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Hong+SB%22">Hong SB</searchLink>; Department of Endocrinology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Huang+HL%22">Huang HL</searchLink>; Department of Cardiology, Cardiac Prevention and Assessment Center, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+YQ%22">Li YQ</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Tang+LL%22">Tang LL</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China; Chinese Society of Clinical Oncology, Beijing 100000, P.R. China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong 510000, P.R. China; Chinese Society of Clinical Oncology, Beijing 100000, P.R. China; Department of Radiation Oncology, Cancer Treatment Center, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P. R. China. Electronic address: majun2@mail.sysu.edu.cn.
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