Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial.

Saved in:
Bibliographic Details
Title: Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial.
Authors: Degaga TS; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Pasaribu AP; Department of Pediatrics, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Tripura R; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ghanchi N; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Rajasekhar M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Adhikari B; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ley B; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Bamboro SA; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Jabbar FA; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Hasibuan N; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Tego TT; Arba Minch General Hospital, Arba Minch, Ethiopia., Zehra S; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Qurashi B; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Mnjala H; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Lee G; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Li P; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Kazi AM; Department of Paediatrics, Aga Khan University, Karachi, Pakistan., Safitri W; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Yulita Y; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Siagian DSP; Batubara District Health Office, North Sumatera, Indonesia., Syahputra D; Batubara District Health Office, North Sumatera, Indonesia., Hadi H; North Sumatera Provincial Health Office, North Sumatera, Indonesia., Muhammad T; Clinical Trial Unit, Aha Khan University, Karachi, Pakistan., Ibrahim A; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Syed N; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Dost K; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Puspitrasari AM; Exeins Health Initiative, Jakarta, Indonesia., Kariodimedjo PP; Exeins Health Initiative, Jakarta, Indonesia., Rai A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Rumaseb A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Sutanto E; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Ean M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Khan A; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Sokha M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Commons RJ; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Weston S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Noviyanti R; Eijkman Research Centre for Molecular Biology, National Research and Innovation, Jakarta, Indonesia., Peto T; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Callery JJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ali U; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Mehmood T; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Dondorp A; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Devine A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Setiawan E; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Mwaura M; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Department of Health Ethics and Society, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands., Cassidy-Seyoum S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Department of Health Ethics and Society, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands., Temesgen R; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Abate DT; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Erjabo EB; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Gessa GG; Arba Minch General Hospital, Arba Minch, Ethiopia., Kiros FG; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Usmani MI; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Raza A; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Woyessa A; Ethiopian Public Health Institute, Addis Abeba, Ethiopia., Hailu A; Addis Abeba University, Addis Abeba, Ethiopia., Simpson JA; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Karahalios A; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Beg MA; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., von Seidlein L; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Dysoley L; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia; National Institute of Public Health, School of Public Health, Phnom Penh, Cambodia., Auburn S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Price RN; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Thriemer K; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. Electronic address: kamala.ley-thriemer@menzies.edu.au.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2026 Jun; Vol. 26 (6), pp. 614-626. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-4457
DOI:10.1016/S1473-3099(25)00729-7