Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial.
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| Title: | Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial. |
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| Authors: | Degaga TS; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Pasaribu AP; Department of Pediatrics, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Tripura R; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ghanchi N; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Rajasekhar M; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Adhikari B; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ley B; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Bamboro SA; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Jabbar FA; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Hasibuan N; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Tego TT; Arba Minch General Hospital, Arba Minch, Ethiopia., Zehra S; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Qurashi B; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Mnjala H; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Lee G; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Li P; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Kazi AM; Department of Paediatrics, Aga Khan University, Karachi, Pakistan., Safitri W; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Yulita Y; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia., Siagian DSP; Batubara District Health Office, North Sumatera, Indonesia., Syahputra D; Batubara District Health Office, North Sumatera, Indonesia., Hadi H; North Sumatera Provincial Health Office, North Sumatera, Indonesia., Muhammad T; Clinical Trial Unit, Aha Khan University, Karachi, Pakistan., Ibrahim A; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Syed N; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Dost K; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Puspitrasari AM; Exeins Health Initiative, Jakarta, Indonesia., Kariodimedjo PP; Exeins Health Initiative, Jakarta, Indonesia., Rai A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Rumaseb A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Sutanto E; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Ean M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Khan A; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Sokha M; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Commons RJ; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Weston S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Noviyanti R; Eijkman Research Centre for Molecular Biology, National Research and Innovation, Jakarta, Indonesia., Peto T; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Callery JJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Ali U; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Mehmood T; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Dondorp A; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Devine A; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Setiawan E; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Mwaura M; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Department of Health Ethics and Society, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands., Cassidy-Seyoum S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Department of Health Ethics and Society, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, Netherlands., Temesgen R; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Abate DT; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Erjabo EB; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Gessa GG; Arba Minch General Hospital, Arba Minch, Ethiopia., Kiros FG; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia., Usmani MI; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Raza A; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Woyessa A; Ethiopian Public Health Institute, Addis Abeba, Ethiopia., Hailu A; Addis Abeba University, Addis Abeba, Ethiopia., Simpson JA; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Karahalios A; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Beg MA; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., von Seidlein L; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Dysoley L; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia; National Institute of Public Health, School of Public Health, Phnom Penh, Cambodia., Auburn S; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia., Price RN; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Thriemer K; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. Electronic address: kamala.ley-thriemer@menzies.edu.au. |
| Source: | The Lancet. Infectious diseases [Lancet Infect Dis] 2026 Jun; Vol. 26 (6), pp. 614-626. Date of Electronic Publication: 2026 Feb 11. |
| Publication Type: | Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41690325 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effectiveness and safety of 7-day high-dose primaquine and single-dose tafenoquine versus 14-day low-dose primaquine in patients with Plasmodium vivax malaria (EFFORT): a multicentre, open-label, randomised, controlled, superiority trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Degaga+TS%22">Degaga TS</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Pasaribu+AP%22">Pasaribu AP</searchLink>; Department of Pediatrics, Medical Faculty, Universitas Sumatera Utara, Medan, Indonesia; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia.<br /><searchLink fieldCode="AU" term="%22Tripura+R%22">Tripura R</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; 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College of Medicine & Health Sciences, Arba Minch University, Arba Minch, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Jabbar+FA%22">Jabbar FA</searchLink>; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hasibuan+N%22">Hasibuan N</searchLink>; Yayasan Penguatan Kesehatan Masyarakat Tridarma (YPKMT; Tridarma Healthcare Empowerment Foundation), Medan, Indonesia.<br /><searchLink fieldCode="AU" term="%22Tego+TT%22">Tego TT</searchLink>; Arba Minch General Hospital, Arba Minch, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Zehra+S%22">Zehra S</searchLink>; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Qurashi+B%22">Qurashi B</searchLink>; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Mnjala+H%22">Mnjala H</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+G%22">Lee G</searchLink>; 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Exeins Health Initiative, Jakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Kariodimedjo+PP%22">Kariodimedjo PP</searchLink>; Exeins Health Initiative, Jakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Rai+A%22">Rai A</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Rumaseb+A%22">Rumaseb A</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Sutanto+E%22">Sutanto E</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Ean+M%22">Ean M</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Sokha+M%22">Sokha M</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Commons+RJ%22">Commons RJ</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Weston+S%22">Weston S</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Noviyanti+R%22">Noviyanti R</searchLink>; Eijkman Research Centre for Molecular Biology, National Research and Innovation, Jakarta, Indonesia.<br /><searchLink fieldCode="AU" term="%22Peto+T%22">Peto T</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; 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Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Woyessa+A%22">Woyessa A</searchLink>; Ethiopian Public Health Institute, Addis Abeba, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Hailu+A%22">Hailu A</searchLink>; Addis Abeba University, Addis Abeba, Ethiopia.<br /><searchLink fieldCode="AU" term="%22Simpson+JA%22">Simpson JA</searchLink>; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Karahalios+A%22">Karahalios A</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Methods and Implementation Support for Clinical Health (MISCH) Research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Beg+MA%22">Beg MA</searchLink>; Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22von+Seidlein+L%22">von Seidlein L</searchLink>; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Dysoley+L%22">Dysoley L</searchLink>; National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia; National Institute of Public Health, School of Public Health, Phnom Penh, Cambodia.<br /><searchLink fieldCode="AU" term="%22Auburn+S%22">Auburn S</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.<br /><searchLink fieldCode="AU" term="%22Price+RN%22">Price RN</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Thriemer+K%22">Thriemer K</searchLink>; Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia. Electronic address: kamala.ley-thriemer@menzies.edu.au. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2026 Jun; Vol. 26 (6), pp. 614-626. <i>Date of Electronic Publication: </i>2026 Feb 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase III; Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130150 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-4457 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214733099%22">14733099 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Infect Dis <i>Subsets: </i>MEDLINE |
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