Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study.
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| Title: | Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study. |
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| Authors: | Siebenhaar F; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany., Broesby-Olsen S; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark., Castells M; Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., George TI; ARUP Laboratories and Huntsman Cancer Institute, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah., Livideanu CB; Department de dermatologie, Expert Centre of Mastocytosis (CEREMAST) CHU de Toulouse, Toulouse University Hospital - Larrey Hospital, Toulouse, France., Álvarez-Twose I; Institute of Mastocytosis Studies of Castilla-La Mancha, Virgen del Valle Hospital, Toledo, Spain., Panse J; Department of Oncology, Hematology, Hemostaseology, and Stem Cell Transplantation, University Hospital Aachen, Medical Faculty, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Aachen, Germany., Barete S; Unit of Dermatology, Reference Centre for Mastocytosis (CEREMAST) Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France., Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Dybedal I; Departments of Hematology and Pharmacology, Oslo University Hospital, Oslo, Norway., Akin C; Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Michigan., Van Daele P; Department of Internal Medicine and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands., Radia DH; Guy's & St Thomas' NHS Foundation Trust, London, UK., Cerquozzi S; Department of Medicine, University of Calgary, Calgary, Alberta, Canada., Ustun C; Section of Bone Marrow Transplantation and Cellular Therapy, Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Rush Medical College, Chicago, Illinois., Sabato V; Department of Immunology, Allergology, and Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium., Gotlib J; Stanford Cancer Institute/Stanford University School of Medicine, Stanford, California., Rafferty M; The Beatson West of Scotland Cancer Centre, Glasgow, Scotland., DeAngelo DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Schafhausen P; Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ungerstedt J; Department of Medicine, Karolinska Institutet, Huddinge, Sweden., Ogbogu PU; Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital; Case Western Reserve University School of Medicine, Cleveland, Ohio., Florell S; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah., Wada DA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah., Rets A; ARUP Laboratories and Huntsman Cancer Institute, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah., Lin HM; Blueprint Medicines Corporation, Cambridge, Massachusetts., Bidollari I; Blueprint Medicines Corporation, Cambridge, Massachusetts., Hong J; Blueprint Medicines Corporation, Cambridge, Massachusetts., Shaheen D; Blueprint Medicines Corporation, Cambridge, Massachusetts., Lampson B; Blueprint Medicines Corporation, Cambridge, Massachusetts., Hartmann K; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: karin.hartmann@usb.ch. |
| Source: | Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2026 Jun; Vol. 94 (6), pp. 1705-1713. Date of Electronic Publication: 2026 Feb 12. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: Mosby Country of Publication: United States NLM ID: 7907132 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6787 (Electronic) Linking ISSN: 01909622 NLM ISO Abbreviation: J Am Acad Dermatol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41690487 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Siebenhaar+F%22">Siebenhaar F</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Broesby-Olsen+S%22">Broesby-Olsen S</searchLink>; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Castells+M%22">Castells M</searchLink>; Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22George+TI%22">George TI</searchLink>; ARUP Laboratories and Huntsman Cancer Institute, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Livideanu+CB%22">Livideanu CB</searchLink>; Department de dermatologie, Expert Centre of Mastocytosis (CEREMAST) CHU de Toulouse, Toulouse University Hospital - Larrey Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Álvarez-Twose+I%22">Álvarez-Twose I</searchLink>; Institute of Mastocytosis Studies of Castilla-La Mancha, Virgen del Valle Hospital, Toledo, Spain.<br /><searchLink fieldCode="AU" term="%22Panse+J%22">Panse J</searchLink>; Department of Oncology, Hematology, Hemostaseology, and Stem Cell Transplantation, University Hospital Aachen, Medical Faculty, RWTH Aachen University, Aachen, Germany; Center for Integrated Oncology (CIO), Aachen, Bonn, Cologne, Düsseldorf (ABCD), Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Barete+S%22">Barete S</searchLink>; Unit of Dermatology, Reference Centre for Mastocytosis (CEREMAST) Pitié-Salpêtrière Hospital, AP-HP, Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Reiter+A%22">Reiter A</searchLink>; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Dybedal+I%22">Dybedal I</searchLink>; Departments of Hematology and Pharmacology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Akin+C%22">Akin C</searchLink>; Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Van+Daele+P%22">Van Daele P</searchLink>; Department of Internal Medicine and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Radia+DH%22">Radia DH</searchLink>; Guy's & St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Cerquozzi+S%22">Cerquozzi S</searchLink>; Department of Medicine, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ustun+C%22">Ustun C</searchLink>; Section of Bone Marrow Transplantation and Cellular Therapy, Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Rush Medical College, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Sabato+V%22">Sabato V</searchLink>; Department of Immunology, Allergology, and Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Gotlib+J%22">Gotlib J</searchLink>; Stanford Cancer Institute/Stanford University School of Medicine, Stanford, California.<br /><searchLink fieldCode="AU" term="%22Rafferty+M%22">Rafferty M</searchLink>; The Beatson West of Scotland Cancer Centre, Glasgow, Scotland.<br /><searchLink fieldCode="AU" term="%22DeAngelo+DJ%22">DeAngelo DJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Schafhausen+P%22">Schafhausen P</searchLink>; Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ungerstedt+J%22">Ungerstedt J</searchLink>; Department of Medicine, Karolinska Institutet, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Ogbogu+PU%22">Ogbogu PU</searchLink>; Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital; Case Western Reserve University School of Medicine, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Florell+S%22">Florell S</searchLink>; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Wada+DA%22">Wada DA</searchLink>; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Rets+A%22">Rets A</searchLink>; ARUP Laboratories and Huntsman Cancer Institute, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Lin+HM%22">Lin HM</searchLink>; Blueprint Medicines Corporation, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bidollari+I%22">Bidollari I</searchLink>; Blueprint Medicines Corporation, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hong+J%22">Hong J</searchLink>; Blueprint Medicines Corporation, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Shaheen+D%22">Shaheen D</searchLink>; Blueprint Medicines Corporation, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lampson+B%22">Lampson B</searchLink>; Blueprint Medicines Corporation, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hartmann+K%22">Hartmann K</searchLink>; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: karin.hartmann@usb.ch. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227907132%22">Journal of the American Academy of Dermatology</searchLink> [J Am Acad Dermatol] 2026 Jun; Vol. 94 (6), pp. 1705-1713. <i>Date of Electronic Publication: </i>2026 Feb 12. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7907132 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6787 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201909622%22">01909622 </searchLink><i>NLM ISO Abbreviation: </i>J Am Acad Dermatol <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jaad.2026.02.025 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1705 Titles: – TitleFull: Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Siebenhaar F – PersonEntity: Name: NameFull: Broesby-Olsen S – PersonEntity: Name: NameFull: Castells M – PersonEntity: Name: NameFull: George TI – PersonEntity: Name: NameFull: Livideanu CB – PersonEntity: Name: NameFull: Álvarez-Twose I – PersonEntity: Name: NameFull: Panse J – PersonEntity: Name: NameFull: Barete S – PersonEntity: Name: NameFull: Reiter A – PersonEntity: Name: NameFull: Dybedal I – PersonEntity: Name: NameFull: Akin C – PersonEntity: Name: NameFull: Van Daele P – PersonEntity: Name: NameFull: Radia DH – PersonEntity: Name: NameFull: Cerquozzi S – PersonEntity: Name: NameFull: Ustun C – PersonEntity: Name: NameFull: Sabato V – PersonEntity: Name: NameFull: Gotlib J – PersonEntity: Name: NameFull: Rafferty M – PersonEntity: Name: NameFull: DeAngelo DJ – PersonEntity: Name: NameFull: Schafhausen P – PersonEntity: Name: NameFull: Ungerstedt J – PersonEntity: Name: NameFull: Ogbogu PU – PersonEntity: Name: NameFull: Florell S – PersonEntity: Name: NameFull: Wada DA – PersonEntity: Name: NameFull: Rets A – PersonEntity: Name: NameFull: Lin HM – PersonEntity: Name: NameFull: Bidollari I – PersonEntity: Name: NameFull: Hong J – PersonEntity: Name: NameFull: Shaheen D – PersonEntity: Name: NameFull: Lampson B – PersonEntity: Name: NameFull: Hartmann K IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1097-6787 Numbering: – Type: volume Value: 94 – Type: issue Value: 6 Titles: – TitleFull: Journal of the American Academy of Dermatology Type: main |
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