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Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury.

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Title: Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury.
Authors: Zhu W; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Jin L; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhang Q; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Cui Y; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zou Y; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Chen P; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Ye J; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Xiong Y; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Lin M; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhou Y; Department of Chemoradiation Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China., Wu R; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Liang Y; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Zhuang Z; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China., Huh JY; College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea., Luo W; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. wuluo@wmu.edu.cn.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. wuluo@wmu.edu.cn.; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. wuluo@wmu.edu.cn., Liang G; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. wzmcliangguang@163.com.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. wzmcliangguang@163.com.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China. wzmcliangguang@163.com.
Source: Nature communications [Nat Commun] 2026 Feb 14; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Jin+L%22">Jin L</searchLink>; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zou+Y%22">Zou Y</searchLink>; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Ye+J%22">Ye J</searchLink>; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Chemoradiation Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Wu+R%22">Wu R</searchLink>; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+Z%22">Zhuang Z</searchLink>; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Huh+JY%22">Huh JY</searchLink>; College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Luo+W%22">Luo W</searchLink>; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. wuluo@wmu.edu.cn.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. wuluo@wmu.edu.cn.; Affiliated Cangnan Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. wuluo@wmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liang+G%22">Liang G</searchLink>; Department of Cardiology and Medical Research Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. wzmcliangguang@163.com.; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. wzmcliangguang@163.com.; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China. wzmcliangguang@163.com.
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